Publication:
G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

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dc.contributor.authorPenela, Petronila
dc.contributor.authorRibas, Catalina
dc.contributor.authorSanchez-Madrid, Francisco
dc.contributor.authorMayor, Federico
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderFundación Ramón Areces
dc.date.accessioned2019-11-14T08:15:16Z
dc.date.available2019-11-14T08:15:16Z
dc.date.issued2019-11
dc.description.abstractAccumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipOur laboratories are supported by Ministerio de Ciencia, Innovación y Universidades (Grant SAF2017-84125-R to FM and SAF2017-82886-R to FSM), CIBERCV-Instituto de Salud Carlos III, Spain (Grant B16/11/00278 to F.M, co-funded with European FEDER contribution), Instituto de Salud Carlos III, Spain (Grant PI17-00576 to PP and grant PI18/01662 to CR), Fundacion Ramón Areces (to FM) and Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FM and FSM. We also acknowledge institutional support to the CBMSO from Fundación Ramón Areceses_ES
dc.format.number22es_ES
dc.format.page4423-4446es_ES
dc.format.volume76es_ES
dc.identifier.citationCell Mol Life Sci. 2019; 76(22):4423-4446es_ES
dc.identifier.doi10.1007/s00018-019-03274-3es_ES
dc.identifier.e-issn1420-9071es_ES
dc.identifier.issn1420-682Xes_ES
dc.identifier.journalCellular and molecular life sciences : CMLSes_ES
dc.identifier.pubmedID31432234es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8581
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-84125-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-82886-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17-00576es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18/01662es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s00018-019-03274-3es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoriaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGPCRes_ES
dc.subjectGRK2es_ES
dc.subjectHDAC6es_ES
dc.subjectInteractomees_ES
dc.subjectPhosphorylationes_ES
dc.titleG protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hubes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication51eb6cbc-309f-4845-987e-5b2cea239c59
relation.isAuthorOfPublication.latestForDiscovery51eb6cbc-309f-4845-987e-5b2cea239c59

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