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Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice

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dc.contributor.authorRodríguez-Izquierdo, Ignacio
dc.contributor.authorCeña-Diez, Rafael
dc.contributor.authorSerramia, Maria Jesús
dc.contributor.authorRodríguez-Fernández, Rosa
dc.contributor.authorMartinez, Isidoro
dc.contributor.authorMuñoz-Fernández, María Ángeles
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERBBN (Bioingeniería, Biomateriales y Nanomedicina)
dc.contributor.funderUnión Europea. European Cooperation in Science and Technology (COST)
dc.contributor.funderPolish National Agency for Academic Exchangees_ES
dc.date.accessioned2022-04-18T07:13:05Z
dc.date.available2022-04-18T07:13:05Z
dc.date.issued2021-06-29
dc.description.abstractThe respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells. A G2-S16 polyanionic carbosilane dendrimer was identified as a possible RSV inhibitor. We speculated that the G2-S16 dendrimer adheres to the host cell-surface HSPG, acts through binding to HS receptors, and prevents further RSV infection. The G2-S16 dendrimer was non-toxic when applied intranasally to Balb/c mice, and interestingly enough, this G2-S16 dendrimer inhibits 85% RSV. Therefore, our G2-S16 dendrimer could be a candidate for developing a new possible therapy against RSV infection.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work has been (partially) funded by the RD16/0025/0019, projects as part of Acción Estratégica en Salud, Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (2013–2016) and co-financed by Instituto de Salud Carlos III (Subdirección General de Evaluación) and Fondo Europeo de Desarrollo Regional (FEDER), RETIC PT17/0015/0042, Fondo de Investigacion Sanitaria (FIS) (grant number PI19/01638) and EPIICAL project. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, the Consolider Program, and CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work has been supported partially by the EUROPARTNER: Strengthening and spreading international partnership activities of the Faculty of Biology and Environmental Protection for interdisciplinary research and innovation of the University of Lodz Programme: NAWA International Academic Partnership Programme. This article/publication is based upon work from COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by COST (European Cooperation in Science and Technology).es_ES
dc.format.number13es_ES
dc.format.page2141es_ES
dc.format.volume13es_ES
dc.identifier.citationPolymers (Basel). 2021;13(13):2141.es_ES
dc.identifier.doi10.3390/polym13132141es_ES
dc.identifier.e-issn2073-4360es_ES
dc.identifier.journalPolymerses_ES
dc.identifier.pubmedID34209827es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13981
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MINECO//RD16%2F0025%2F0019/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN SIDA (RIS)/es_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/null/PLATAFORMAS DE APOYO A LA INVESTIGACION EN CIENCIAS Y TECNOLOGIAS DE LA SALUD (2017)/PT17/0015/0042es_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI19 - Proyectos de investigacion en salud (AES 2019). Modalidad proyectos en salud. (2019)/PI19/01638es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement//EC/CA 17140es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/polym13132141es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectG2-S16 dendrimeres_ES
dc.subjectRSV infectiones_ES
dc.subjectNanotechnologyes_ES
dc.subjectSyncytiumes_ES
dc.titleRole of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Micees_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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