Publication:
Recommendations for measuring HIV reservoir size in cure-directed clinical trials.

Simple item page
dc.contributor.authorAbdel-Mohsen, Mohamed
dc.contributor.authorRichman, Douglas
dc.contributor.authorSiliciano, Robert F
dc.contributor.authorNussenzweig, Michel C
dc.contributor.authorHowell, Bonnie J
dc.contributor.authorMartinez-Picado, Javier
dc.contributor.authorChomont, Nicolas
dc.contributor.authorBar, Katharine J
dc.contributor.authorYu, Xu G
dc.contributor.authorLichterfeld, Mathias
dc.contributor.authorAlcamí, José
dc.contributor.authorHazuda, Daria
dc.contributor.authorBushman, Frederic
dc.contributor.authorSiliciano, Janet D
dc.contributor.authorBetts, Michael R
dc.contributor.authorSpivak, Adam M
dc.contributor.authorPlanelles, Vicente
dc.contributor.authorHahn, Beatrice H
dc.contributor.authorSmith, Davey M
dc.contributor.authorHo, Ya-Chi
dc.contributor.authorGaebler, Christian
dc.contributor.authorPaiardini, Mirko
dc.contributor.authorLi, Qingsheng
dc.contributor.authorEstes, Jacob D
dc.contributor.authorHope, Thomas J
dc.contributor.authorKostman, Jay
dc.contributor.authorMounzer, Karam
dc.contributor.authorCaskey, Marina
dc.contributor.authorFox, Lawrence
dc.contributor.authorFrank, Ian
dc.contributor.authorRiley, James L
dc.contributor.authorTebas, Pablo
dc.contributor.authorMontaner, Luis J
dc.contributor.authorBuzon, Maria J
dc.contributor.funderNational Institutes of Health (Estados Unidos)
dc.contributor.funderInstituto de Salud Carlos III
dc.date.accessioned2021-03-03T12:21:04Z
dc.date.available2021-03-03T12:21:04Z
dc.date.issued2020
dc.description.abstractTherapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will require a consensus on how best to measure the numbers of persistently infected cells with the potential to cause viral rebound after antiretroviral-therapy cessation in assessing the results of cure-directed strategies in vivo. Current measurements assess various aspects of the HIV provirus and its functionality and produce divergent results. Here, we provide recommendations from the BEAT-HIV Martin Delaney Collaboratory on which viral measurements should be prioritized in HIV-cure-directed clinical trials.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by the NIH-funded BEAT-HIV Martin Delaney Collaboratory to cure HIV-1 infection (1UM1Al126620). LJM is also supported by NIH R01 AI065279, U01 AI065279, R01 DA048728, R01 DA049666, Kean Family Professorship, and the Philadelphia Foundation (Roberts I. Jacobs Fund). M-AM is supported by NIH grants (DK123733, AG062383, NS117458, AI143385, AI129636, and NS106970), The Foundation for AIDS Research (amfAR) impact grant # 109840–65-RGRL, and W.W. Smith Charitable Trust grant # A1901, Wistar Cancer Center Support Grant P30 CA010815–49S2, and the Penn Center for AIDS Research (AI 045008). MJB is supported by The Miguel Servet program funded by the Spanish Health Institute Carlos III (CP17/00179). M. L. Is supported by NIH grants AI117841, AI120008, AI124776, AI130005, AI122377, and AI135940. XGY is supported by NIH grants AI116228, AI078799, HL134539, AI125109, and DA047034. RS supported by AI126603, AI126620 and AI12661, AI094189, 43222 Howard Hughes Medical Institute, and the Bill and Melinda Gates Foundation (OPP1115715). VP supported by AI143567, AI124843. Y-C Ho supported by Yale Top Scholar, Rudolf J. Anderson Fellowship, AI141009, DA047037, AI118402, W.W. Smith AIDS Research Grant, Gilead AIDS Research Grant, Gilead Research Scholar Grant, AI150464, AI094189, AI14868. J.D.E is supported by NIH and the Bill and Melinda Gates Foundation grants 75N93019C00070, AI133706, AI110164, AI141258, AI143411, AI149672, CA206466, DK119945, INV-002704, and OD011092–60, and OPPO1108533.es_ES
dc.format.number9es_ES
dc.format.page1339-1350es_ES
dc.format.volume26es_ES
dc.identifier.citationNat Med . 2020 Sep;26(9):1339-1350.es_ES
dc.identifier.doi10.1038/s41591-020-1022-1es_ES
dc.identifier.e-issn1546-170Xes_ES
dc.identifier.journalNature medicinees_ES
dc.identifier.pubmedID32895573es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12088
dc.language.isoenges_ES
dc.publisherNature Publishing Group
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP17/00179es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41591-020-1022-1es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHIV latencyes_ES
dc.subjectHIV reservoirses_ES
dc.subjectViral measurementses_ES
dc.subjectHIV Curees_ES
dc.subjectHIV persistencees_ES
dc.subjectReplication-competent HIVes_ES
dc.subject.meshAnti-Retroviral Agentses_ES
dc.subject.meshCD4-Positive T-Lymphocyteses_ES
dc.subject.meshClinical Trials as Topices_ES
dc.subject.meshDisease Reservoirses_ES
dc.subject.meshHIV Infectionses_ES
dc.subject.meshHIV-1es_ES
dc.subject.meshHumanses_ES
dc.subject.meshMass Screeninges_ES
dc.subject.meshViral Loades_ES
dc.subject.meshVirus Latencyes_ES
dc.titleRecommendations for measuring HIV reservoir size in cure-directed clinical trials.es_ES
dc.typeresearch articlees_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication2fc55aca-54b0-411c-b170-c2149068a902
relation.isAuthorOfPublication.latestForDiscovery2fc55aca-54b0-411c-b170-c2149068a902
relation.isFunderOfPublicationd863b318-3e6b-4cfc-81bb-a6d112b1f86e
relation.isFunderOfPublication7d739953-4b68-4675-b5bb-387a9ab74b66
relation.isFunderOfPublication.latestForDiscoveryd863b318-3e6b-4cfc-81bb-a6d112b1f86e
relation.isPublisherOfPublication301fb00e-338e-4f8c-beaa-f9d8f4fefcc0
relation.isPublisherOfPublication.latestForDiscovery301fb00e-338e-4f8c-beaa-f9d8f4fefcc0

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
RecommendationsForMeasuringHIV_2020.pdf
Size:
480.04 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Centro Nacional de Microbiología (CNM)
IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)