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Impact of optical tissue clearing on the Brillouin signal from biological tissue samples

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dc.contributor.authorRiobóo, Rafael J. Jiménez
dc.contributor.authorDesco, Manuel
dc.contributor.authorGómez-Gaviro, María Victoria
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderFundación ProCNIC
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)
dc.date.accessioned2019-07-03T14:03:54Z
dc.date.available2019-07-03T14:03:54Z
dc.date.issued2019-06
dc.description.abstractBrillouin spectroscopy is a well-established technology in condensed matter physics to characterize the mechanical properties of inert materials, and it has been extended very recently to the study of biological samples. Transparency is beneficial for samples to be properly analyzed by Brillouin spectroscopy. Here, we explored the efficacy of optical tissue clearing techniques to improve the acquisition of Brillouin spectra from biological tissues in order to analyze their biomechanical properties. We describe the first application of Brillouin scattering to optically cleared biological tissues with CUBIC protocol. We conclude that, within the range of error, tissue clearing does not modify the mechanical properties of the studied biological tissues.es_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades, the Pro CNIC Foundation, Severo Ochoa Center of Excellence (SEV-2015-0505); ISCIII-FIS grants PI18/00462 co-financed by ERDF, European Union (FEDER) Funds from the European Commission, European Union, “A way of making Europe”; MINECO/FEDER (MAT2015-65356-C3-1-R); Comunidad de Madrid Vol. 10, No. 6 | 1 Jun 2019 | BIOMEDICAL OPTICS EXPRESS 2681 (PHAMA 2.0-CM S2013/MIT-2740); CIBER de Salud Mental (CIBERSAM) and COSTaction CA16124.es_ES
dc.format.number6es_ES
dc.format.page2674es_ES
dc.format.volume10es_ES
dc.identifier.citationBiomed Opt Express. 2019; 10(6):2674-2683es_ES
dc.identifier.doi10.1364/BOE.10.002674es_ES
dc.identifier.issn2156-7085es_ES
dc.identifier.journalBiomedical Optics Expresses_ES
dc.identifier.pubmedID31259043es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7848
dc.language.isoenges_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18 - Proyectos de investigacion en salud (AES 2018). Modalidad proyectos en salud. (2018)/PI18/00462
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MAT2015-65356-C3-1-Res_ES
dc.relation.publisherversionhttps://doi.org/10.1364/boe.10.002674es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleImpact of optical tissue clearing on the Brillouin signal from biological tissue sampleses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication3d8c68c5-1cf7-41e7-bc20-a44a703ae994
relation.isAuthorOfPublication.latestForDiscovery3d8c68c5-1cf7-41e7-bc20-a44a703ae994

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