Publication:
MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM

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dc.contributor.authorPernaute, Barbara
dc.contributor.authorSpruce, Thomas
dc.contributor.authorSmith, Kimberley M
dc.contributor.authorSánchez-Nieto, Juan Miguel
dc.contributor.authorManzanares, Miguel
dc.contributor.authorCobb, Bradley
dc.contributor.authorRodríguez, Tristan A
dc.contributor.funderFundación ProCNIC
dc.contributor.funderMedical Research Council (Reino Unido)
dc.contributor.funderEuropean Molecular Biology Organization
dc.contributor.funderUnión Europea. Comisión Europea
dc.date.accessioned2019-03-18T14:01:40Z
dc.date.available2019-03-18T14:01:40Z
dc.date.issued2014-09-01
dc.description.abstractMammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipM.M. was supported by the Spanish Government and the ProCNIC Foundation. This work was supported by the Medical Research Council (MR/K00090X/1), EMBO (ALTF 1340-2010), and the European Commission (PIEF-GA-2010-273884 - MEMD).es_ES
dc.format.number17es_ES
dc.format.page1873-8es_ES
dc.format.volume28es_ES
dc.identifier.citationGenes Dev. 2014; 28(17):1873-8es_ES
dc.identifier.doi10.1101/gad.245621.114es_ES
dc.identifier.e-issn1549-5477es_ES
dc.identifier.issn0890-9369es_ES
dc.identifier.journalGenes & developmentes_ES
dc.identifier.pubmedID25184675es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7353
dc.language.isoenges_ES
dc.publisherCold Spring Harbor Laboratory Presses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/273884/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.1101/gad.245621.114es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genómica Funcionales_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBimes_ES
dc.subjectDiceres_ES
dc.subjectApoptosises_ES
dc.subjectEpiblastes_ES
dc.subjectmicroRNAses_ES
dc.subjectPluripotencyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshApoptosises_ES
dc.subject.meshApoptosis Regulatory Proteinses_ES
dc.subject.meshBcl-2-Like Protein 11es_ES
dc.subject.meshCell Survivales_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshGene Expression Profilinges_ES
dc.subject.meshMembrane Proteinses_ES
dc.subject.meshMicees_ES
dc.subject.meshMicroRNAses_ES
dc.subject.meshMitochondriaes_ES
dc.subject.meshPluripotent Stem Cellses_ES
dc.subject.meshProto-Oncogene Proteinses_ES
dc.subject.meshGene Expression Regulation, Developmentales_ES
dc.titleMicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIMes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication56c10503-dda9-492f-86f2-9107563c6aab
relation.isAuthorOfPublication.latestForDiscovery56c10503-dda9-492f-86f2-9107563c6aab

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