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A canine leishmaniasis pilot survey in an emerging focus of visceral leishmaniasis: Posadas (Misiones, Argentina)

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dc.contributor.authorCruz, Israel
dc.contributor.authorAcosta, Lucrecia
dc.contributor.authorGutiƩrrez, Mariana N
dc.contributor.authorNieto Martinez, Francisco Javier
dc.contributor.authorCaƱavate, Carmen
dc.contributor.authorDeschutter, Jorge
dc.contributor.authorBornay-Llinares, Fernando Jorge
dc.contributor.funderGeneralitat Valenciana (EspaƱa)
dc.contributor.funderUniĆ³n Europea. ComisiĆ³n Europea. 6 Programa Marco
dc.date.accessioned2019-03-12T12:22:52Z
dc.date.available2019-03-12T12:22:52Z
dc.date.issued2010-12-01
dc.description.abstractBACKGROUND: An increasing number of reports are calling our attention to the worldwide spread of leishmaniasis. The urbanization of zoonotic visceral leishmaniasis (VL) has been observed in different South American countries, due to changes in demographic and ecological factors. In May 2006, VL was detected for the first time in the city of Posadas (Misiones, Argentina). This event encouraged us to conduct a clinical and parasitological pilot survey on domestic dogs from Posadas to identify their potential role as reservoirs for the disease. METHODS: One hundred and ten dogs from the city of Posadas were included in the study. They were selected based on convenience and availability. All dogs underwent clinical examination. Symptomatology related to canine leishmaniasis was recorded, and peripheral blood and lymph node aspirates were collected. Anti-Leishmania antibodies were detected using rK39-immunocromatographic tests and IFAT. Parasite detection was based on peripheral blood and lymph node aspirate PCR targeting the SSUrRNA gene. Molecular typing was addressed by DNA sequence analysis of the PCR products obtained by SSUrRNA and ITS-1 PCR. RESULTS: According to clinical examination, 69.1% (76/110) of the dogs presented symptoms compatible with canine leishmaniasis. Serological analyses were positive for 43.6% (48/110) of the dogs and parasite DNA was detected in 47.3% (52/110). A total of 63 dogs (57.3%) were positive by serology and/or PCR. Molecular typing identified Leishmania infantum (syn. Leishmania chagasi) as the causative agent. CONCLUSIONS: This work confirms recent findings which revealed the presence of Lutzomyia longipalpis, the vector of L. infantum in this area of South America. This new VL focus could be well established, and further work is needed to ascertain its magnitude and to prevent further human VL cases.es_ES
dc.description.peerreviewedSĆ­es_ES
dc.description.sponsorshipThis work was supported by: DirecciĆ³n General de CooperaciĆ³n alDesarrollo, Generalitat Valenciana, Spain. And European Commission 6th Framework Programme INCO-CT-2005-015407 (Control strategies for visceralleishmaniasis (VL) and mucocutaneous leishmaniasis (MCL) in South America:Applications of molecular epidemiology/LeishEpiNetSA).es_ES
dc.format.number1es_ES
dc.format.page342es_ES
dc.format.volume10es_ES
dc.identifier.citationBMC Infect Dis. 2010 Dec 1;10:342.es_ES
dc.identifier.doi10.1186/1471-2334-10-342es_ES
dc.identifier.issn1471-2334es_ES
dc.identifier.journalBMC infectious diseaseses_ES
dc.identifier.pubmedID21122107es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7328
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/015407es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2334-10-342es_ES
dc.repisalud.centroISCIII::Centro Nacional de MicrobiologĆ­aes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribuciĆ³n 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimalses_ES
dc.subject.meshArgentinaes_ES
dc.subject.meshDisease Reservoirses_ES
dc.subject.meshDog Diseaseses_ES
dc.subject.meshDogses_ES
dc.subject.meshFemalees_ES
dc.subject.meshLeishmania infantumes_ES
dc.subject.meshLeishmaniasis, Viscerales_ES
dc.subject.meshMalees_ES
dc.subject.meshPilot Projectses_ES
dc.subject.meshSeroepidemiologic Studieses_ES
dc.titleA canine leishmaniasis pilot survey in an emerging focus of visceral leishmaniasis: Posadas (Misiones, Argentina)es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublicationb3dc07dc-ad41-46f7-b8a2-9446c6cab831
relation.isAuthorOfPublicationa516ec77-01ab-401d-b750-215d5e6a3cde
relation.isAuthorOfPublication.latestForDiscovery4ca3b46e-2faa-4a7d-a134-d198c24d7475
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