Publication:
The alternative heart: impact of alternative splicing in heart disease

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dc.contributor.authorLara-Pezzi, Enrique
dc.contributor.authorGomez-Salinero, Jesus M.
dc.contributor.authorGatto, Alberto
dc.contributor.authorGarcía-Pavía, Pablo
dc.contributor.funderUnión Europea. Comisión Europea
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.date.accessioned2019-07-26T14:34:22Z
dc.date.available2019-07-26T14:34:22Z
dc.date.issued2013-12
dc.description.abstractAlternative splicing is the main driver of protein diversity and allows the production of different proteins from each gene in the genome. Changes in exon exclusion, intron retention or the use of alternative splice sites can alter protein structure, localisation, regulation and function. In the heart, alternative splicing of sarcomeric genes, ion channels and cell signalling proteins can lead to cardiomyopathies, arrhythmias and other pathologies. Also, a number of inherited conditions and heart-related diseases develop as a result of mutations affecting splicing. Here, we review the impact that changes in alternative splicing have on individual genes and on whole biological processes associated with heart disease. We also discuss promising therapeutic tools based on the manipulation of alternative splicing.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipEuropean Union [ITN-289600]; Spanish Ministry of Economy [SAF2012-31451]; Madrid Regional Government [S2010/BMD-2321]; Instituto de Salud Carlos III (Red Enfermedades Cardiovasculares) [RD12/0042/0002]es_ES
dc.format.number6es_ES
dc.format.page945-55es_ES
dc.format.volume6es_ES
dc.identifier.citationJ Cardiovasc Transl Res. 2013; 6(6):945-55es_ES
dc.identifier.doi10.1007/s12265-013-9482-zes_ES
dc.identifier.e-issn1937-5395es_ES
dc.identifier.issn1937-5387es_ES
dc.identifier.journalJournal of cardiovascular translational researches_ES
dc.identifier.pubmedID23775418es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7969
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/289600/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2012-31451es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0042/0002es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s12265-013-9482-zes_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiacaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalses_ES
dc.subject.meshCalcium Signalinges_ES
dc.subject.meshGene Expression Regulationes_ES
dc.subject.meshGenetic Predisposition to Diseasees_ES
dc.subject.meshGenetic Therapyes_ES
dc.subject.meshHeart Diseaseses_ES
dc.subject.meshHumanses_ES
dc.titleThe alternative heart: impact of alternative splicing in heart diseasees_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicatione7d4df9b-2306-4955-ba22-17d066e07612
relation.isAuthorOfPublication617db269-573b-425a-87c7-7061a461bdd5
relation.isAuthorOfPublication029a5418-972f-42a1-acef-cec7a44fe50b
relation.isAuthorOfPublication.latestForDiscoverye7d4df9b-2306-4955-ba22-17d066e07612

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