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A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.

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dc.contributor.authorKamoun, Aurélie
dc.contributor.authorde Reyniès, Aurélien
dc.contributor.authorAllory, Yves
dc.contributor.authorSjödahl, Gottfrid
dc.contributor.authorRobertson, A Gordon
dc.contributor.authorSeiler, Roland
dc.contributor.authorHoadley, Katherine A
dc.contributor.authorGroeneveld, Clarice S
dc.contributor.authorAl-Ahmadie, Hikmat
dc.contributor.authorChoi, Woonyoung
dc.contributor.authorCastro, Mauro A A
dc.contributor.authorFontugne, Jacqueline
dc.contributor.authorEriksson, Pontus
dc.contributor.authorMo, Qianxing
dc.contributor.authorKardos, Jordan
dc.contributor.authorZlotta, Alexandre
dc.contributor.authorHartmann, Arndt
dc.contributor.authorDinney, Colin P
dc.contributor.authorBellmunt, Joaquim
dc.contributor.authorPowles, Thomas
dc.contributor.authorMalats, Núria
dc.contributor.authorChan, Keith S
dc.contributor.authorKim, William Y
dc.contributor.authorMcConkey, David J
dc.contributor.authorBlack, Peter C
dc.contributor.authorDyrskjøt, Lars
dc.contributor.authorHöglund, Mattias
dc.contributor.authorLerner, Seth P
dc.contributor.authorReal Arribas, Francisco
dc.contributor.authorRadvanyi, François
dc.contributor.funderSwedish Cancer Society (Cancerfonden)es_ES
dc.contributor.funderLund Medical Faculty (ALF)es_ES
dc.date.accessioned2024-02-14T10:13:05Z
dc.date.available2024-02-14T10:13:05Z
dc.date.issued2020-04
dc.description.abstractBACKGROUND Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application. OBJECTIVE To achieve an international consensus on MIBC molecular subtypes that reconciles the published classification schemes. DESIGN, SETTING, AND PARTICIPANTS We used 1750 MIBC transcriptomic profiles from 16 published datasets and two additional cohorts. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS We performed a network-based analysis of six independent MIBC classification systems to identify a consensus set of molecular classes. Association with survival was assessed using multivariable Cox models. RESULTS AND LIMITATIONS We report the results of an international effort to reach a consensus on MIBC molecular subtypes. We identified a consensus set of six molecular classes: luminal papillary (24%), luminal nonspecified (8%), luminal unstable (15%), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%). These consensus classes differ regarding underlying oncogenic mechanisms, infiltration by immune and stromal cells, and histological and clinical characteristics, including outcomes. We provide a single-sample classifier that assigns a consensus class label to a tumor sample's transcriptome. Limitations of the work are retrospective clinical data collection and a lack of complete information regarding patient treatment. CONCLUSIONS This consensus system offers a robust framework that will enable testing and validation of predictive biomarkers in future prospective clinical trials. PATIENT SUMMARY Bladder cancers are heterogeneous at the molecular level, and scientists have proposed several classifications into sets of molecular classes. While these classifications may be useful to stratify patients for prognosis or response to treatment, a consensus classification would facilitate the clinical use of molecular classes. Conducted by multidisciplinary expert teams in the field, this study proposes such a consensus and provides a tool for applying the consensus classification in the clinical setting.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work is part of the French national program Cartes d'Identite des Tumeurs (CIT; http://cit.ligue-cancer.net). The results presented in this study are partly based upon data generated by TCGA project established by the NCI and NHGRI. Information about TCGA and the investigators and institutions that constitute the TCGA research network can be found at http://cancergenome.nih.gov/. The results presented in this study are partly based on datasets financed by grants from the Swedish Cancer Society (2017/278) and Lund Medical Faculty (ALF). We are grateful to the patients who participated in the studies that made the work reported here possible.es_ES
dc.format.number4es_ES
dc.format.page420es_ES
dc.format.volume77es_ES
dc.identifier.citationEur Urol . 2020 ;77(4):420-433es_ES
dc.identifier.doi10.1016/j.eururo.2019.09.006es_ES
dc.identifier.e-issn1873-7560es_ES
dc.identifier.journalEuropean urologyes_ES
dc.identifier.pubmedID31563503es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18196
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.eururo.2019.09.006es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Carcinogénesis Epiteliales_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAgedes_ES
dc.titleA Consensus Molecular Classification of Muscle-invasive Bladder Cancer.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication62d13a40-e75d-49b1-bb0a-f54a4146ad3e
relation.isAuthorOfPublication.latestForDiscovery62d13a40-e75d-49b1-bb0a-f54a4146ad3e
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