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Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate plus Theobromine

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dc.contributor.authorHernández, Yumaira
dc.contributor.authorCosta-Bauza, Antonia
dc.contributor.authorCalvó García, Paula
dc.contributor.authorBenejam Gual, Joan Maria
dc.contributor.authorSanchis, Pilar
dc.contributor.authorGrases, Felix
dc.date.accessioned2024-09-13T09:14:45Z
dc.date.available2024-09-13T09:14:45Z
dc.date.issued2020-07
dc.description.abstractBackground. Uric acid (UA) renal lithiasis has a high rate of recurrence and a prevalence ranging from 10% and 15%, depending on the population. The most important etiological factor is persistence of urinary pH below 5.5 and one of the most common treatments is alkalization with citrate. Recent studies demonstrated that theobromine, which is abundant in chocolate and cocoa, is a potent inhibitor of UA crystallization. Aim. The aim was to compare the efficacy of citrate versus citrate + theobromine as treatment for UA lithiasis. Methods. This randomized cross-over trial investigated the efficacy of two treatments in 47 patients with UA renal lithiasis. Urine volume, pH, UA excretion, theobromine excretion, and risk of UA crystallization (RUAC) at baseline and at the end of each intervention period were measured. Results. Each treatment significantly reduced the risk of UA crystallization compared to basal values. The RUAC after citrate + theobromine was lower than the RUAC after citrate, although this difference was not statistically significant. Conclusion. The combined consumption of citrate and theobromine may be a promising strategy for the prevention of UA kidney stones.en
dc.format.number7es_ES
dc.format.page2012es_ES
dc.format.volume12es_ES
dc.identifier.citationHernandez Y, Costa-Bauza A, Calvo P, Benejam J, Sanchis P, Grases F. Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate plus Theobromine. Nutrients. 2020 Jul;12(7):2012.en
dc.identifier.doi10.3390/nu12072012
dc.identifier.e-issn2072-6643es_ES
dc.identifier.journalNutrientses_ES
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/10187
dc.identifier.pubmedID32645831es_ES
dc.identifier.puiL2004673791
dc.identifier.scopus2-s2.0-85087802036
dc.identifier.urihttps://hdl.handle.net/20.500.12105/22975
dc.identifier.wos558645600001
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://dx.doi.org/10.3390/nu12072012en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectUric acid
dc.subjectUrolithiasis
dc.subjectTheobromine
dc.subjectDietary treatment
dc.subject.decsResultado del Tratamiento*
dc.subject.decsFemenino*
dc.subject.decsÁcido úrico*
dc.subject.decsTeobromina*
dc.subject.decsMasculino*
dc.subject.decsMétodo Doble Ciego*
dc.subject.decsConcentración de Iones de Hidrógeno*
dc.subject.decsCálculos Renales*
dc.subject.decsCombinación de Medicamentos*
dc.subject.decsHumanos*
dc.subject.decsPersona de Mediana Edad*
dc.subject.decsRecurrencia*
dc.subject.decsAnciano*
dc.subject.decsEstudios Cruzados*
dc.subject.decsNefrolitiasis*
dc.subject.decsSuplementos Dietéticos*
dc.subject.decsÁcido Cítrico*
dc.subject.meshAged*
dc.subject.meshCitric Acid*
dc.subject.meshDrug Combinations*
dc.subject.meshCross-Over Studies*
dc.subject.meshKidney Calculi*
dc.subject.meshHumans*
dc.subject.meshHydrogen-Ion Concentration*
dc.subject.meshMiddle Aged*
dc.subject.meshDouble-Blind Method*
dc.subject.meshUric Acid*
dc.subject.meshNephrolithiasis*
dc.subject.meshRecurrence*
dc.subject.meshMale*
dc.subject.meshTheobromine*
dc.subject.meshFemale*
dc.subject.meshTreatment Outcome*
dc.subject.meshDietary Supplements*
dc.titleComparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate plus Theobromineen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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