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Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.

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URI: http://hdl.handle.net/20.500.12105/18526
DOI: 10.3390/ijms23010247
Full text access: http://hdl.handle.net/10668/21127

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2021-12-27

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Abstract

Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value

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MCAO hyaluronate nanoparticles neuroglobin neuroprotection proteomics stroke

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Animals Blood-Brain Barrier Brain Infarction Endocytosis Gene Ontology Infarction, Middle Cerebral Artery Magnetic Resonance Imaging Male Nanoparticles Neuroglobin Neurons Neuroprotective Agents Nitrosative Stress Oxidative Stress Principal Component Analysis Proteomics Rats, Wistar Stroke Survival Analysis Thiobarbituric Acid Reactive Substances

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IBIMA-Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (Andalucía)

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