Publication:
Natural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy: A prospective cohort study

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dc.contributor.authorDel Romero, Jorge
dc.contributor.authorBaza, María Begoña
dc.contributor.authorRío, Isabel
dc.contributor.authorJerónimo, Adrián
dc.contributor.authorVera, Mar
dc.contributor.authorHernando Sebastian, Victoria
dc.contributor.authorRodríguez, Carmen
dc.contributor.authorCastilla Catalán, Jesús
dc.date.accessioned2020-04-21T08:37:58Z
dc.date.available2020-04-21T08:37:58Z
dc.date.issued2016-07
dc.description.abstractThe potential of antiretroviral treatment (ART) to prevent the sexual transmission of HIV has increased the number of serodiscordant couples who are considering natural conception. We aim to describe the results of a protocol for reproductive counseling aimed at HIV serodiscordant couples who desire natural conception, in which the infected partner, the index case, is receiving suppressive antiretroviral treatment.A prospective cohort included all HIV serodiscordant couples attended a counseling program in the period 2002 to 2013 who opted for natural conception and met the following criteria: index case on ART with persistent plasma viral suppression for at least the previous 6 months, ART compliance over 95%, preserved immune status, undetectable HIV viral and proviral load in semen in male index cases, and absence of genitourinary infections and fertility problems in both members of the couple.Of the 161 HIV serodiscordant couples included, 133 with male index cases, 66% achieved at least 1 pregnancy, 18% a second one, and 5% a third pregnancy. A total of 144 natural pregnancies occurred and 107 babies were born. The pregnancy rate was 1.9 for each 100 acts of vaginal intercourse, and the mean time to conception was 6.1 months, both independently of the sex of the index case. No case of sexual or vertical HIV transmission occurred.In the absence of fertility problems and under controlled conditions, natural conception might be a safe and effective reproductive method for those HIV serodiscordant couples who choose this reproductive option.es_ES
dc.description.peerreviewedSíes_ES
dc.format.number30es_ES
dc.format.pagee4398es_ES
dc.format.volume95es_ES
dc.identifier.citationMedicine (Baltimore) . 2016 Jul;95(30):e4398.es_ES
dc.identifier.doi10.1097/MD.0000000000004398es_ES
dc.identifier.e-issn1536-5964es_ES
dc.identifier.issn0025-7974es_ES
dc.identifier.journalMedicinees_ES
dc.identifier.pubmedID27472733es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9640
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkins (LWW)es_ES
dc.relation.publisherversionhttps://doi.org/10.1097/MD.0000000000004398es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdultes_ES
dc.subject.meshAnti-HIV Agentses_ES
dc.subject.meshCohort Studieses_ES
dc.subject.meshFemalees_ES
dc.subject.meshFertilizationes_ES
dc.subject.meshHumanses_ES
dc.subject.meshInfant, Newbornes_ES
dc.subject.meshMalees_ES
dc.subject.meshPregnancyes_ES
dc.subject.meshProspective Studieses_ES
dc.subject.meshReproductive Techniques, Assistedes_ES
dc.subject.meshSpaines_ES
dc.subject.meshHIV Seronegativityes_ES
dc.subject.meshSex Counselinges_ES
dc.subject.meshSexual Partnerses_ES
dc.titleNatural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy: A prospective cohort studyes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
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