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Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

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dc.contributor.authorPires Simoes, Margarida
dc.contributor.authorHodcroft, Emma B
dc.contributor.authorSimmonds, Peter
dc.contributor.authorAlbert, Jan
dc.contributor.authorAlidjinou, Enagnon K
dc.contributor.authorAmbert-Balay, Katia
dc.contributor.authorAndrés, Cristina
dc.contributor.authorAntón, Andrés
dc.contributor.authorAuvray, Christelle
dc.contributor.authorBailly, Jean-Luc
dc.contributor.authorBaldanti, Fausto
dc.contributor.authorBastings, Capser
dc.contributor.authorBeard, Stuart
dc.contributor.authorBerengua, Carla
dc.contributor.authorBerginc, Natasa
dc.contributor.authorBloemen, Mandy
dc.contributor.authorBlomqvist, Soile
dc.contributor.authorBosma, Froukje
dc.contributor.authorBöttcher, Sindy
dc.contributor.authorBubba, Laura
dc.contributor.authorBuderus, Stafan
dc.contributor.authorCabrerizo, Maria
dc.contributor.authorCalvo, Cristina
dc.contributor.authorCelma, Cristina
dc.contributor.authorCeriotti, Ferruccio
dc.contributor.authorClark, Gemma
dc.contributor.authorCosta, Inës
dc.contributor.authorCoste-Burel, Marianne
dc.contributor.authorCouderé, Karen
dc.contributor.authorCremer, Jeroen
dc.contributor.authorDel Cuerpo Casas, Margarita
dc.contributor.authorDaehne, Theo
dc.contributor.authorde Beer, Jessica
dc.contributor.authorde Ceano-Vivas, Maria
dc.contributor.authorDe Gascun, Cillian
dc.contributor.authorde Rougemont, Alexis
dc.contributor.authorDean, Jonathan
dc.contributor.authorDembinski, Jennifer L
dc.contributor.authorDiedrich, Sabine
dc.contributor.authorDiez-Domingo, Javier
dc.contributor.authorDillner, Lena
dc.contributor.authorDorenberg, Dagny H
dc.contributor.authorDucancelle, Alexandra
dc.contributor.authorDudman, Susanne
dc.contributor.authorDyrdak, Robert
dc.contributor.authorEis-Huebinger, Anna-Maria
dc.contributor.authorFalces-Romero, Iker
dc.contributor.authorFarkas, Agnes
dc.contributor.authorFeeney, Susan
dc.contributor.authorFernandez-Garcia, Maria Dolores
dc.contributor.authorFlipse, Jacky
dc.contributor.authorFranck, Kristina T
dc.contributor.authorGalli, Cristina
dc.contributor.authorGarrigue, Isabelle
dc.contributor.authorGeeraedts, Felix
dc.contributor.authorGeorgieva, Irina
dc.contributor.authorGiardina, Federica
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorHauzenberger, Elenor
dc.contributor.authorHeikens, Esther
dc.contributor.authorHenquell, Cécille
dc.contributor.authorHober, Didier
dc.contributor.authorHönemann, Mario
dc.contributor.authorHowson-Wells, Hannah
dc.contributor.authorHruškar, Željka
dc.contributor.authorIkonen, Niina
dc.contributor.authorImbert, Berthemarie
dc.contributor.authorJansz, Arjan R
dc.contributor.authorJeannoël, Marion
dc.contributor.authorJiřincová, Helena
dc.contributor.authorJosset, Laurence
dc.contributor.authorKeeren, Kathrin
dc.contributor.authorKramer-Lindhout, Naomie
dc.contributor.authorKrokstad, Sidsel
dc.contributor.authorLazrek, Mouna
dc.contributor.authorLe Guillou-Guillemette, Hélène
dc.contributor.authorLefeuvre, Caroline
dc.contributor.authorLind, Andreas
dc.contributor.authorLunar, Maja M
dc.contributor.authorMaier, Melanie
dc.contributor.authorMarque-Juillet, Stéphanie
dc.contributor.authorMcClure, C Patrick
dc.contributor.authorMcKenna, James
dc.contributor.authorMeijer, Adam
dc.contributor.authorMenasalvas Ruiz, Ana
dc.contributor.authorMengual-Chuliá, Beatriz
dc.contributor.authorMidgley, Sofie
dc.contributor.authorMirand, Audrey
dc.contributor.authorMolenkamp, Richard
dc.contributor.authorMontes, Milagrosa
dc.contributor.authorMoreno-Docón, Antonio
dc.contributor.authorMorley, Ursula
dc.contributor.authorMurk, Jean-Luc
dc.contributor.authorNavascués-Ortega, Ana
dc.contributor.authorNijhuis, Roel
dc.contributor.authorNikolaeva-Glomb, Lubomira
dc.contributor.authorNordbø, Svein A
dc.contributor.authorNumanovic, Sanela
dc.contributor.authorOggioni, Massimo
dc.contributor.authorOñate Vergara, Eider
dc.contributor.authorPacaud, Jordi
dc.contributor.authorPacreau, Marie L
dc.contributor.authorPanning, Marcus
dc.contributor.authorPariani, Elena
dc.contributor.authorPekova, Lili
dc.contributor.authorPellegrinelli, Laura
dc.contributor.authorPetrovec, Miroslav
dc.contributor.authorPietsch, Corinna
dc.contributor.authorPilorge, Léa
dc.contributor.authorPiñeiro, Luis
dc.contributor.authorPiralla, Antonio
dc.contributor.authorPoljak, Mario
dc.contributor.authorProchazka, Birgit
dc.contributor.authorRabella, Nuria
dc.contributor.authorRahamat-Langendoen, Janette C
dc.contributor.authorRainetova, Petra
dc.contributor.authorReynders, Marijke
dc.contributor.authorRiezebos-Brilman, Annelies
dc.contributor.authorRoorda, Lieuwe
dc.contributor.authorSavolainen-Kopra, Carita
dc.contributor.authorSchuffenecker, Isabelle
dc.contributor.authorSmeets, Leo C
dc.contributor.authorStoyanova, Asya
dc.contributor.authorStefic, Karl
dc.contributor.authorSwanink, Caroline
dc.contributor.authorTabain, Irena
dc.contributor.authorTjhie, Jeroen
dc.contributor.authorThouault, Luc
dc.contributor.authorTumiotto, Camille
dc.contributor.authorUceda Renteria, Sara
dc.contributor.authorUršič, Tina
dc.contributor.authorVallet, Sophie
dc.contributor.authorVan Ranst, Marc
dc.contributor.authorVan Wunnik, Peter
dc.contributor.authorVerweij, Jaco J
dc.contributor.authorVila, Jorgina
dc.contributor.authorWintermans, Bas
dc.contributor.authorWollants, Elke
dc.contributor.authorWolthers, Katja C
dc.contributor.authorXavier López-Labrador, F
dc.contributor.authorFischer, Thea Kølsen
dc.contributor.authorHarvala, Heli
dc.contributor.authorBenschop, Kimberley SM
dc.contributor.funderAustrian Federal Ministry of Health (Austria)
dc.contributor.funderMinistry of Health (República Checa)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
dc.contributor.funderSanté Publique France
dc.contributor.funderUnión Europea. Comisión Europea. NextGenerationEU
dc.contributor.funderMinistry of Health Welfare and Sport (Países Bajos)
dc.contributor.funderNational Institutes of Health (Estados Unidos)
dc.contributor.funderSlovenian Research Agency
dc.contributor.funderSwiss National Science Foundation
dc.date.accessioned2025-03-12T13:24:53Z
dc.date.available2025-03-12T13:24:53Z
dc.date.issued2024-10-16
dc.description.abstractEnterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.
dc.description.peerreviewedSí
dc.description.sponsorshipThe study was funded by: Austrian Ministry of Health (AT01), Czechia Ministry of Health (CZ01), and Project PI18CIII-00035, Foundation for Influenza Epidemiology for data collection and CIBEResp (Instituto de Salud Carlos III, Spain; ES05) for research researcher grants (FXL, JDD and BMC ES06); Santé Publique France (FR01); EU partial funding within the NextGeneration EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project no. PE00000007, INF-ACT, IT01 and IT02 ); Ministry of Health, Welfare and Sport, The Netherlands (NL02) and National Health insurance (NL01, NL03-NL12); National Surveillance program (SI01), internal funds and by the Slovenian Research Agency [grant number P3-0083] (SI02); and, by The UK Clinical Virology Network (UK04). E. B. H. is supported by the Swiss National Science Foundation through grant number 31CA30_196046.
dc.format.number4
dc.format.pagee917-e928
dc.format.volume230
dc.identifier.citationSimoes MP, Hodcroft EB, Simmonds P, et al.. Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study. J Infect Dis. 2024 Oct 16;230(4):e917-e928.
dc.identifier.doi10.1093/infdis/jiae154
dc.identifier.e-issn1537-6613
dc.identifier.issn0022-1899
dc.identifier.journalThe Journal of infectious diseases
dc.identifier.pubmedID38547499
dc.identifier.urihttps://hdl.handle.net/20.500.12105/26435
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18CIII-00035
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/PE00000007
dc.relation.publisherversionhttps://doi.org/10.1093/infdis/jiae154
dc.repisalud.centroISCIII::Centro Nacional de Microbiología (CNM)
dc.repisalud.institucionISCIII
dc.repisalud.instituteIIS::IR-HUVH - Instituto de Investigación Hospital Universitari Vall d’Hebron (Cataluña)
dc.repisalud.instituteIIS::IdiPAZ - Instituto de Investigación Sanitaria Hospital La Paz (Madrid)
dc.repisalud.instituteIIS::IIS BioDonostia - Instituto de Investigación Sanitaria Biodonostia (País Vasco)
dc.repisalud.instituteIIS::IMIB - Instituto Murciano de Investigación Biosanitaria Pascual Parrilla (Murcia)
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEuropean Non-Polio Enterovirus Network (ENPEN)
dc.subjectAcute flaccid myelitis (AFM)
dc.subjectEnterovirus D68 (EV-D68)
dc.subjectNonpolio enterovirus (NPEV)
dc.subjectRespiratory infection
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCentral Nervous System Viral Diseases
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshEnterovirus D, Human
dc.subject.meshEnterovirus Infections
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMyelitis
dc.subject.meshNeuromuscular Diseases
dc.subject.meshPhylogeny
dc.subject.meshRespiratory Tract Infections
dc.subject.meshYoung Adult
dc.titleEpidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
dc.typeresearch article
dc.type.hasVersionVoR
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