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Vascular co-option in brain metastasis.

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dc.contributor.authorGarcía-Gómez, Pedro
dc.contributor.authorValiente, Manuel
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
dc.contributor.funderBristol-Myers Squibb
dc.contributor.funderBeug Foundation for Metastasis Research
dc.contributor.funderFundación Ramón Areces
dc.contributor.funderWorldwide Cancer Research
dc.contributor.funderUnión Europea. Comisión Europea. H2020
dc.contributor.funderCancer Research Institute (CRI). Clinic & Laboratory Integration Program (CLIP)
dc.contributor.funderAsociación Española Contra el Cáncer
dc.contributor.funderFundación La Caixa
dc.contributor.funderMarie Curie
dc.date.accessioned2022-10-14T09:01:16Z
dc.date.available2022-10-14T09:01:16Z
dc.date.issued2020-02
dc.description.abstractVascular co-option by brain metastasis-initiating cells has been demonstrated as a critical step in organ colonization. The physical interaction between the cancer cell and the endothelial cell is mediated by integrins and L1CAM and could be involved in aggressive growth but also latency and immune evasion. The key involvement of vascular co-option in brain metastasis has created an emerging field that aims to identify critical targets as well as effective inhibitors with the goal of preventing brain metastases.es_ES
dc.description.peerreviewedNoes_ES
dc.description.sponsorshipResearch in the Brain Metastasis Group is supported by MINECO-Retos SAF2017-89643-R (M.V.), Bristol-Myers Squibb-Melanoma Research Alliance Young Investigator Award (498103) (M.V.), Beug Foundation's Prize for Metastasis Research (M.V.), Fundacion Ramon Areces (CIVP19S8163) (M. V.), Worldwide Cancer Research (19-0177) (M.V.), H2020-FETOPEN (828972) (M.V.), CLIP Award Cancer Research Institute (54545) (M.V.), and AECC Coordinated Translational Groups 2017 (GCTRA16015SEOA) (M.V.). P.G-G. is the recipient of La Caixa Foundation (ID100010434) and European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement (No. 713673) PhD Program Fellowship (LCF/BQ/IN17/11620028). M.V. is a Ramon y Cajal Investigator (RYC-2013-13365) and EMBO YIP (4053).es_ES
dc.format.number1es_ES
dc.format.page3-8es_ES
dc.format.volume23es_ES
dc.identifier.citationAngiogenesis . 2020 ;23(1):3-8.es_ES
dc.identifier.doi10.1007/s10456-019-09693-xes_ES
dc.identifier.e-issn1573-7209es_ES
dc.identifier.journalAngiogenesises_ES
dc.identifier.pubmedID31701335es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15052
dc.language.isoenges_ES
dc.publisherSpringer
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/SAF2017-89643-Res_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CIVP19S8163es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/GCTRA16015SEOAes_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/ID100010434es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/828972/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/713673/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s10456-019-09693-x.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Metástasis Cerebrales_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAnimalses_ES
dc.subject.meshBrain Neoplasmses_ES
dc.subject.meshCell Adhesiones_ES
dc.subject.meshCell Proliferationes_ES
dc.subject.meshHumanses_ES
dc.subject.meshModels, Biologicales_ES
dc.subject.meshNeoplasm Invasivenesses_ES
dc.subject.meshNeovascularization, Pathologices_ES
dc.titleVascular co-option in brain metastasis.es_ES
dc.typepreprintes_ES
dc.type.hasVersionSMURes_ES
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