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Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension.

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dc.contributor.authorGarcia-Lunar, Ines
dc.contributor.authorPereda, Daniel
dc.contributor.authorIbáñez, Borja
dc.contributor.authorGarcia-Alvarez, Ana
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderFundación ProCNIC
dc.date.accessioned2021-06-29T06:28:17Z
dc.date.available2021-06-29T06:28:17Z
dc.date.issued2020-11
dc.description.abstractThe autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting both systems in this condition, particularly in Groups 1 and 2. State of the art knowledge in preclinical and clinical use of pharmacologic drugs (beta-blockers, beta-three adrenoceptor agonists, or renin-angiotensin-aldosterone signaling drugs) and invasive procedures, such as pulmonary artery denervation, is provided.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was partially funded by Fondo Europeo de Desarrollo Regional (FEDER) Instituto de Salud Carlos III-Fondo de Investigación Sanitaria PI17/00995 and Intensificación AES2019 to Dr. García-Álvarez. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Part of this work was developed at the Centre de Recerca Biomèdica Cellex, IDIBAPS, Barcelona. The IDIBAPS belongs to the CERCA Programme and receives partial funding from the Generalitat de Catalunya.es_ES
dc.format.number11es_ES
dc.format.page2521es_ES
dc.format.volume9es_ES
dc.identifier.citationCells. 2020; 9(11):2521es_ES
dc.identifier.doi10.3390/cells9112521es_ES
dc.identifier.issn2073-4409es_ES
dc.identifier.journalCellses_ES
dc.identifier.pubmedID33266371es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13205
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PI17/00995es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/cells9112521es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNeurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication92018446-2b00-4798-a27d-d2b26871b81b
relation.isAuthorOfPublication.latestForDiscoveryde903570-4c8c-4bcb-8cfe-d077154694e0

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