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Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?

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dc.contributor.authorCarrero, Laura
dc.contributor.authorAntequera, Desireé
dc.contributor.authorMunicio, Cristina
dc.contributor.authorCarro, Eva
dc.date.accessioned2024-03-18T14:36:16Z
dc.date.available2024-03-18T14:36:16Z
dc.date.issued2024
dc.description.abstractDysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer's disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer's disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.es_ES
dc.description.peerreviewedSíes_ES
dc.format.number9es_ES
dc.format.page1967-1972es_ES
dc.format.volume19es_ES
dc.identifier.citationNeural Regen Res. 2024;19(9):1967-1972.es_ES
dc.identifier.doi10.4103/1673-5374.390962es_ES
dc.identifier.issn1673-5374es_ES
dc.identifier.journalNeural regeneration researches_ES
dc.identifier.pubmedID38227523es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18993
dc.language.isoenges_ES
dc.publisherWolters Kluwer
dc.relation.publisherversionhttps://doi.org/10.4103/1673-5374.390962es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAlzheimer’s diseasees_ES
dc.subjectAmyloides_ES
dc.subjectCircadian rhythmes_ES
dc.subjectNeurodegenerationes_ES
dc.subjectRetinaes_ES
dc.titleCircadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?es_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication8421fdf3-fae7-41aa-a4c1-8656ef386e2b
relation.isAuthorOfPublication.latestForDiscoveryaac62b7d-2264-493f-a641-b74cf145920c
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relation.isPublisherOfPublication.latestForDiscoveryb2ca5f78-d34e-49de-aa94-ad7eb84e67f6

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