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Leptin Supplementation During Lactation Restores Key Liver Metabolite Levels Malprogrammed by Gestational Calorie Restriction

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dc.contributor.authorYau-Qiu, Zhi Xin
dc.contributor.authorMadrid-Gambin, Francisco
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorPalou, Andreu
dc.contributor.authorRodriguez, Ana Maria
dc.date.accessioned2024-09-18T06:45:06Z
dc.date.available2024-09-18T06:45:06Z
dc.date.issued2021-08
dc.description.abstractIntroduction: Perinatal nutritional factors can program offspring metabolic phenotype and risk to obesity. This study investigates the potential role of leptin supplementation (during lactation) in ameliorating the malprogrammed effects caused by mild maternal calorie restriction during gestation, on young rat offspring liver metabolic response. Methods and Results: Untargeted and targeted metabolomics studies on liver samples are performed by NMR and GC-MS, respectively. Global DNA methylation and the expression by RT-PCR of key genes involved in different pathways are also determined. By NMR, 15 liver metabolites are observed to be altered in the offspring of gestational calorie-restricted dams (CR group), at days 25-27 of life. Physiological leptin supplementation during lactation partially reverted the effect of CR condition for most of these metabolites. Moreover, targeted fatty acid analysis by GC-MS shows a significant decrease in the hepatic concentration of certain very long-chain fatty acids (VLCFA) in CR offspring, partially or totally reverted by leptin supplementation. No remarkable changes are found in global DNA methylation or mRNA expression. Conclusion: Physiological leptin supplementation during lactation contributes to the reversion of changes caused by maternal mild calorie restriction on the liver metabolome. This agrees with a putative role of leptin supplementation preventing or reversing metabolic disturbances caused by gestational metabolic malprogramming.en
dc.description.sponsorshipThe research leading to these results was supported by the founding of the Spanish Government (grant reference AGL2015-67019-P, PI: AP). L.B. acknowledges funding from Department Agriculture Food and the Marine (15F685). Z.X.Q. was granted with a PhD fellowship funded by the Spanish Government (grant reference FPU014/0386).es_ES
dc.format.number16es_ES
dc.format.page2001046es_ES
dc.format.volume65es_ES
dc.identifier.citationYau-Qiu ZX, Madrid-Gambin F, Brennan L, Palou A, Rodriguez AM. Leptin Supplementation During Lactation Restores Key Liver Metabolite Levels Malprogrammed by Gestational Calorie Restriction. Mol Nutr Food Res. 2021 Aug;65(16):2001046.en
dc.identifier.doi10.1002/mnfr.202001046
dc.identifier.e-issn1613-4133es_ES
dc.identifier.issn1613-4125
dc.identifier.journalMolecular Nutrition & Food Researches_ES
dc.identifier.otherhttps://hdl.handle.net/20.500.13003/19666
dc.identifier.pubmedID33900028es_ES
dc.identifier.puiL634883258
dc.identifier.scopus2-s2.0-85111796250
dc.identifier.urihttps://hdl.handle.net/20.500.12105/23356
dc.identifier.wos680066000001
dc.language.isoengen
dc.publisherWiley
dc.relation.publisherversionhttps://dx.doi.org/10.1002/mnfr.202001046en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCalorie restriction
dc.subjectLeptin
dc.subjectLiver
dc.subjectMetabolic programming
dc.subjectPerinatal nutrition
dc.subject.decsAnimales*
dc.subject.decsFenómenos Fisiologicos Nutricionales Maternos*
dc.subject.decsRatas Wistar*
dc.subject.decsFemenino*
dc.subject.decsHígado*
dc.subject.decsMasculino*
dc.subject.decsRestricción Calórica*
dc.subject.decsLactancia*
dc.subject.decsRatas*
dc.subject.decsIngestión de Energía*
dc.subject.decsÁcidos Grasos*
dc.subject.decsEmbarazo*
dc.subject.decsMetilación de ADN*
dc.subject.decsLeptina*
dc.subject.decsMetaboloma*
dc.subject.meshMaternal Nutritional Physiological Phenomena*
dc.subject.meshEnergy Intake*
dc.subject.meshDNA Methylation*
dc.subject.meshFatty Acids*
dc.subject.meshLactation*
dc.subject.meshPregnancy*
dc.subject.meshLiver*
dc.subject.meshMale*
dc.subject.meshMetabolome*
dc.subject.meshRats, Wistar*
dc.subject.meshLeptin*
dc.subject.meshFemale*
dc.subject.meshRats*
dc.subject.meshAnimals*
dc.subject.meshCaloric Restriction*
dc.titleLeptin Supplementation During Lactation Restores Key Liver Metabolite Levels Malprogrammed by Gestational Calorie Restrictionen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublicationd81e762a-95f7-4917-88a1-8004b3b8caa7
relation.isPublisherOfPublication.latestForDiscoveryd81e762a-95f7-4917-88a1-8004b3b8caa7

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