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Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis

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dc.contributor.authorMagro-Lopez, Esmeralda
dc.contributor.authorChamorro-Herrero, Irene
dc.contributor.authorZambrano, Alberto
dc.contributor.funderInstituto de Salud Carlos III
dc.date.accessioned2022-11-17T13:50:10Z
dc.date.available2022-11-17T13:50:10Z
dc.date.issued2022-04-28
dc.description.abstractIn our previous work, we evaluated the therapeutic effects of 1α,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in the context of bleomycin-induced lung fibrosis. Contrary to the expected, vitamin D supplementation increased the DNA damage expression and cellular senescence in alveolar epithelial type II cells and aggravated the overall lung pathology induced in mice by bleomycin. These effects were probably due to an alteration in the cellular DNA double-strand breaks' repair capability. In the present work, we have evaluated the effects of two hypocalcemic vitamin D analogs (calcipotriol and paricalcitol) in the expression of DNA damage in the context of minilungs derived from human embryonic stem cells and in the cell line A549.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by Grant PI19CIII/00003 from the Institute of Health Carlos III (ISCIII) to Alberto Zambrano.es_ES
dc.format.number9es_ES
dc.format.page4921es_ES
dc.format.volume23es_ES
dc.identifier.citationInt J Mol Sci. 2022 Apr 28;23(9):4921.es_ES
dc.identifier.doi10.3390/ijms23094921es_ES
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.identifier.pubmedID35563311es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15179
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI19CIII/00003es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms23094921es_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHuman pluripotent stem cellses_ES
dc.subjecthESCses_ES
dc.subjectMinilungses_ES
dc.subjectVitamin Des_ES
dc.subjectVitamin D analogses_ES
dc.subjectParicalcitoles_ES
dc.subjectCalcipotrioles_ES
dc.subjectLung fibrosises_ES
dc.subject.meshHuman Embryonic Stem Cellses_ES
dc.subject.meshPulmonary Fibrosises_ES
dc.subject.meshAnimalses_ES
dc.subject.meshBleomycines_ES
dc.subject.meshDNA Damagees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMicees_ES
dc.subject.meshVitamin Des_ES
dc.titleEffects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosises_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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