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Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma

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dc.contributor.authorPérez-Ruiz, Elisabeth
dc.contributor.authorGutiérrez, Vanesa
dc.contributor.authorMuñoz, Marta
dc.contributor.authorOliver, Javier
dc.contributor.authorSánchez, Marta
dc.contributor.authorGálvez-Carvajal, Laura
dc.contributor.authorRueda-Domínguez, Antonio
dc.contributor.authorBarragán, Isabel
dc.contributor.authoraffiliation[Pérez-Ruiz,E; Gutiérrez,V; Muñoz,M; Gálvez-Carvajal,L; Rueda-Domínguez,A] Unidad de Gestión Clínica Intercentros de Oncología Médica, Oncology Department, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Oliver,J; Barragán,I] Researcher Unit, Unidad de Gestión Clínica Intercentros de Oncología Médica, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Sánchez,M] Maxillofacial Surgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain. [Barragán,I] Group of Pharmacoepigenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
dc.date.accessioned2024-02-19T15:31:44Z
dc.date.available2024-02-19T15:31:44Z
dc.date.issued2021-10-15
dc.description.abstractOral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.
dc.description.sponsorshipE.P.-R. has received a grant from The Spanish Society of Medical Oncology (SEOM). IB has received funding (project SA 0263/2017, Nicolás Monardes Program) from the Consejería de Salud y Familias, Junta de Andalucía, Spain.
dc.identifier.doi10.3390/biomedicines9101478
dc.identifier.e-issn2227-9059es_ES
dc.identifier.journalBiomedicineses_ES
dc.identifier.otherhttp://hdl.handle.net/10668/4333
dc.identifier.pubmedID34680596es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18485
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/9/10/1478/htmes
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOral cell carcinoma
dc.subjectField cancerization
dc.subjectLiquid biopsy
dc.subjectTobacco
dc.subjectSaliva
dc.subjectEarly diagnosis
dc.subjectCarcinoma de células escamosas de cabeza y cuello
dc.subjectBiopsia líquida
dc.subjectTabaco
dc.subjectDiagnóstico precoz
dc.subjectDetección precoz del cáncer
dc.subject.meshMouth Neoplasms
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshTobacco
dc.subject.meshSaliva
dc.subject.meshGoals
dc.subject.meshNeoplasms, Second Primary
dc.titleLiquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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