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Amyloid Precursor Protein (APP) Regulates Gliogenesis and Neurogenesis of Human Neural Stem Cells by Several Signaling Pathways

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dc.contributor.authorCoronel Lopez, Raquel
dc.contributor.authorBernabeu-Zornoza, Adela
dc.contributor.authorPalmer, Charlotte
dc.contributor.authorGonzález-Sastre, Rosa
dc.contributor.authorRosca, Andreea
dc.contributor.authorMateos-Martínez, Patricia
dc.contributor.authorLópez-Alonso, Victoria
dc.contributor.authorListe-Noya, Isabel
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)es_ES
dc.contributor.funderUniversity of Alcalá (España)es_ES
dc.date.accessioned2023-09-26T12:46:26Z
dc.date.available2023-09-26T12:46:26Z
dc.date.issued2023-08-19
dc.description.abstractNumerous studies have focused on the pathophysiological role of amyloid precursor protein (APP) because the proteolytic processing of APP to β-amyloid (Aβ) peptide is a central event in Alzheimer's disease (AD). However, many authors consider that alterations in the physiological functions of APP are likely to play a key role in AD. Previous studies in our laboratory revealed that APP plays an important role in the differentiation of human neural stem cells (hNSCs), favoring glial differentiation (gliogenesis) and preventing their differentiation toward a neuronal phenotype (neurogenesis). In the present study, we have evaluated the effects of APP overexpression in hNSCs at a global gene level by a transcriptomic analysis using the massive RNA sequencing (RNA-seq) technology. Specifically, we have focused on differentially expressed genes that are related to neuronal and glial differentiation processes, as well as on groups of differentially expressed genes associated with different signaling pathways, in order to find a possible interaction between them and APP. Our data indicate a differential expression in genes related to Notch, Wnt, PI3K-AKT, and JAK-STAT signaling, among others. Knowledge of APP biological functions, as well as the possible signaling pathways that could be related to this protein, are essential to advance our understanding of AD.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis research was supported by a grant from the Spanish Ministry of Science and Innovation (RTI2018-101663-B-100) and grant number PID2021-126715OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. R.C. was supported by FPU predoctoral contract from Universidad de Alcalá (FPU-UAH).es_ES
dc.format.number16es_ES
dc.format.page12964es_ES
dc.format.volume24es_ES
dc.identifier.citationInt J Mol Sci. 2023 Aug 19;24(16):12964.es_ES
dc.identifier.doi10.3390/ijms241612964es_ES
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.identifier.pubmedID37629148es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16512
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/RTI2018-101663-B-100es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PID2021-126715OB-I00es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms241612964es_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAmyloid precursor proteines_ES
dc.subjectNeural stem cellses_ES
dc.subjectNeurogenesises_ES
dc.subjectGliogenesises_ES
dc.subjectSignaling pathwayses_ES
dc.subjectRNA sequencinges_ES
dc.subject.meshNeural Stem Cellses_ES
dc.subject.meshAlzheimer Diseasees_ES
dc.subject.meshHumanses_ES
dc.subject.meshAmyloid beta-Protein Precursores_ES
dc.subject.meshPhosphatidylinositol 3-Kinaseses_ES
dc.subject.meshNeurogenesises_ES
dc.subject.meshSignal Transductiones_ES
dc.titleAmyloid Precursor Protein (APP) Regulates Gliogenesis and Neurogenesis of Human Neural Stem Cells by Several Signaling Pathwayses_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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