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Dengue nanosensors: a roadmap for clinical viability.

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dc.contributor.authorCodina Márquez, Helena
dc.contributor.authorQuero-Delgado, Marta
dc.contributor.authorGómez, Rafael
dc.contributor.authorResino, Salvador
dc.contributor.authorMartinez, Isidoro
dc.contributor.authorSepulveda-Crespo, Daniel
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
dc.contributor.funderUnión Europea. Comisión Europea. NextGenerationEU
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERBBN (Bioingeniería, Biomateriales y Nanomedicina)
dc.date.accessioned2026-06-26T20:59:03Z
dc.date.available2026-06-26T20:59:03Z
dc.date.issued2026-02-26
dc.description.abstractDengue nanosensors promise much but have failed in clinical application. This paradox stems from a focus on record sensitivity over real-world robustness. We propose a paradigm shift from materials discovery to product engineering, providing a translational roadmap to guide viable diagnostics from the lab bench to the patient.
dc.description.peerreviewedSí
dc.description.sponsorshipThis work was supported by grants from Instituto de Salud Carlos III (ISCIII; grant # PI23CIII/00018 to DSC and IM, PI19CIII/00009 to IM) and CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB 2021), ISCIII, Ministerio de Ciencia e Innovación, and Unión Europea – NextGenerationEU: CIBERINFEC (CB21/13/00044 to SR) and CIBER-BBN (CB06/01/1021 to RG). DSC is a ‘Miguel Servet’ researcher from ISCIII (grant #CP23CIII/00004).
dc.identifier.citationCodina H, Quero-Delgado M, Gómez R, Resino S, Martínez I, Sepúlveda-Crespo D. Dengue nanosensors: a roadmap for clinical viability. Trends Biotechnol. 2026 Feb 26:S0167-7799(26)00005-3. doi: 10.1016/j.tibtech.2026.01.005. Epub ahead of print. PMID: 41760427.
dc.identifier.doi10.1016/j.tibtech.2026.01.005
dc.identifier.journalTrends in Biotechnology
dc.identifier.pubmedID41760427
dc.identifier.urihttps://hdl.handle.net/20.500.12105/27568
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Proyectos de Investigación en Salud-AESI/PI23CIII%2F00018//Nanosistemas dentríticos aplicados al diagnóstico de infecciones virales/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19CIII%2F00009//Desarrollo de un ensayo de diagnóstico rápido para el cribado de la infección activa del virus de la hepatitis C basado en la detección del core/VHCAgc
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII-CIBER-Ministerio de Ciencia e Innovación-Unión Europea–NextGenerationEU//CB21%2F13%2F00044/ES//
dc.relation.projectIDinfo:eu-repo/grantAgreement/CIBER-BBN//CB06%2F01%2F1021/ES//
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//CP23CIII%2F00004/ES//
dc.relation.publisherversionhttps://doi.org/10.1016/j.tibtech.2026.01.005
dc.repisalud.centroISCIII::Centro Nacional de Microbiología (CNM)
dc.repisalud.institucionISCIII
dc.rights.accessRightsembargoed access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectClinical translation
dc.subjectDengue virus
dc.subjectNanosensors
dc.subjectPoint-of-care (PoC) diagnostics
dc.subjectSensor validation
dc.titleDengue nanosensors: a roadmap for clinical viability.
dc.typeresearch article
dc.type.hasVersionAM
dspace.entity.typePublication
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