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Oleuropein and Cancer Chemoprevention: The Link is Hot

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dc.contributor.authorFarooqi, Ammad Ahmad
dc.contributor.authorFayyaz, Sundas
dc.contributor.authorSanches Silva, Ana
dc.contributor.authorSoldevila Verdeguer, Carla
dc.contributor.authorNabavi, Seyed Fazel
dc.contributor.authorMocan, Andrei
dc.contributor.authorNabavi, Seyed Mohammad
dc.contributor.authorBishayee, Anupam
dc.date.accessioned2024-07-11T09:10:31Z
dc.date.available2024-07-11T09:10:31Z
dc.date.issued2017-05
dc.description.abstractCancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed.en
dc.description.sponsorshipThis article is the outcome of an in-house financially non-supported study. A. Sureda was partially supported by the Spanish Ministry of Health, Social Services and Equality (CIBEROBN-B12/03/30038). A. Mocan acknowledges funding from UEFISCDI, Romania, project no. PNII-RU-TE-2014-4-1247.es_ES
dc.format.number5es_ES
dc.format.page705es_ES
dc.format.volume22es_ES
dc.identifier.citationFarooqi Ammad A, Fayyaz S, Sanches Silva A, Sureda Gomila A, Nabavi Seyed F, Mocan A, et al. Oleuropein and Cancer Chemoprevention: The Link is Hot. Molecules. 2017 May;22(5):705.en
dc.identifier.doi10.3390/molecules22050705
dc.identifier.issn1420-3049
dc.identifier.journalMoleculeses_ES
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/9839
dc.identifier.pubmedID28468276es_ES
dc.identifier.puiL617825666
dc.identifier.scopus2-s2.0-85020222655
dc.identifier.urihttp://hdl.handle.net/20.500.12105/20427
dc.identifier.wos404522900028
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://dx.doi.org/10.3390/molecules22050705en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCancer
dc.subjectChemopreventive effect
dc.subjectOleuropein
dc.subjectOlive oil
dc.subject.decsAnimales*
dc.subject.decsAnticarcin�genos*
dc.subject.decsHumanos*
dc.subject.decsNeoplasias*
dc.subject.decsInhibidores de Proteínas Quinasas*
dc.subject.decsQuimioprevención*
dc.subject.decsIridoides*
dc.subject.decsApoptosis*
dc.subject.decsSistema de Señalización de MAP Quinasas*
dc.subject.meshChemoprevention*
dc.subject.meshApoptosis*
dc.subject.meshMAP Kinase Signaling System*
dc.subject.meshAnimals*
dc.subject.meshAnticarcinogenic Agents*
dc.subject.meshHumans*
dc.subject.meshProtein Kinase Inhibitors*
dc.subject.meshIridoids*
dc.subject.meshNeoplasms*
dc.titleOleuropein and Cancer Chemoprevention: The Link is Hoten
dc.typereview articleen
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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