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Biological Versus Chronological Aging: JACC Focus Seminar

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dc.contributor.authorHamczyk, Magda R.
dc.contributor.authorNevado, Rosa M
dc.contributor.authorBarettino, Ana
dc.contributor.authorFuster, Valentin
dc.contributor.authorAndres, Vicente
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderFundación ProCNIC
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)
dc.contributor.funderFundación La Marató TV3
dc.date.accessioned2020-03-30T13:44:24Z
dc.date.available2020-03-30T13:44:24Z
dc.date.issued2020-03-03
dc.description.abstractAging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThe CNIC is supported by the MCNU, the ISCIII, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Work in Dr. Andrés’ laboratory is supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (MCNU) (SAF2016-79490-R) and the Instituto de Salud Carlos III (ISCIII) (AC16/00091, AC17/00067, and CB16/11/00405) with cofunding from the European Regional Development Fund (ERDF/FEDER, “Una manera de hacer Europa”) and the Fundació Marató TV3 (122/C/2015). Dr. Hamczyk is supported by the MCNU (post-doctoral contract FJCI-2017-33299). Ms. Nevado is supported by the Ministerio de Educación, Cultura y Deporte (pre-doctoral contract FPU16/05027). Ms. Barettino is supported by the MCNU (pre-doctoral contract BES-2017-079705).es_ES
dc.format.number8es_ES
dc.format.page919-930es_ES
dc.format.volume75es_ES
dc.identifier.citationJ Am Coll Cardiol. 2020; 75(8):919-930es_ES
dc.identifier.doi10.1016/j.jacc.2019.11.062es_ES
dc.identifier.e-issn1558-3597es_ES
dc.identifier.issn07351097es_ES
dc.identifier.journalJournal of the American College of Cardiologyes_ES
dc.identifier.pubmedID32130928es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9367
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2016-79490-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AC16/00091es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AC17/00067es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CB16/11/00405es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FPU16/05027es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2017-079705es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jacc.2019.11.062es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genéticaes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntiaging therapyes_ES
dc.subjectBiological agees_ES
dc.subjectBiological age biomarkerses_ES
dc.subjectChronological agees_ES
dc.subjectVascular diseasees_ES
dc.titleBiological Versus Chronological Aging: JACC Focus Seminares_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryf315c565-17c9-4492-a087-f77cddd7fe88

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