Publication:
Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish

Simple item page
dc.contributor.authorSande-Melon, Marcos
dc.contributor.authorMarques, Ines Joao
dc.contributor.authorGalardi-Castilla, Maria
dc.contributor.authorLanga, Xavier
dc.contributor.authorPérez-López, María
dc.contributor.authorBotos, Marius-Alexandru
dc.contributor.authorSanchez-Iranzo, Hector
dc.contributor.authorGuzman-Martinez, Gabriela
dc.contributor.authorFerreira Francisco, David Miguel
dc.contributor.authorPavlinic, Dinko
dc.contributor.authorBenes, Vladimir
dc.contributor.authorBruggmann, Rémy
dc.contributor.authorMercader, Nadia
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderSwiss National Science Foundation
dc.contributor.funderUnión Europea. Comisión Europea
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderFundación ProCNIC
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.date.accessioned2019-10-31T10:44:45Z
dc.date.available2019-10-31T10:44:45Z
dc.date.issued2019-10
dc.description.abstractDuring heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work has been funded by the Spanish Ministry of Economy and Competitiveness (BFU2014–56970–P), the Swiss National Science Foundation (grant 31003A_159721), the ERC (starting grant 337703–zebra–Heart), Comunidad de Madrid (FIBROTEAM S2010/BMD-2321), and co-funding by Fondo Europeo de Desarrollo Regional (FEDER). I.J.M. was supported by Marie Curie Slodowska fellowship (PIEF-A-2012-330728). D.F. was supported by BtRAIN (European Brain Barriers Training Network) (H2020-MSCA-ITN-2015, n 675619). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovacion y Universidades (MCNU), and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.format.number4es_ES
dc.format.page1041-1054.e5es_ES
dc.format.volume29es_ES
dc.identifier.citationCell Rep. 2019; 29(4):1041-1054es_ES
dc.identifier.doi10.1016/j.celrep.2019.09.041es_ES
dc.identifier.e-issn2211-1247es_ES
dc.identifier.issn22111247es_ES
dc.identifier.journalCell reportses_ES
dc.identifier.pubmedID31644901es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8539
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/337703es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/330728es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/675619es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2014–56970–Pes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.celrep.2019.09.041es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Desarrollo del Epicardio y su Papel en la Regeneraciónes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCardiomyocyte proliferationes_ES
dc.subjectHeart regenerationes_ES
dc.subjectSox10es_ES
dc.subjectZebrafishes_ES
dc.titleAdult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafishes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationf050e7df-c2c4-4601-83bb-0c9f3fdfda88
relation.isAuthorOfPublicationb7d05c5a-71bf-4a85-97e0-3bb7c7370856
relation.isAuthorOfPublication1bae402c-725c-4e30-a852-3788efc66986
relation.isAuthorOfPublication736ddfcf-41a8-49a0-81d1-37f6b51ec43c
relation.isAuthorOfPublication7fd024a3-1c84-4372-9a1c-c46e178b032e
relation.isAuthorOfPublication6ea1cf51-a1c1-4666-8ba5-18c1ac9487ad
relation.isAuthorOfPublication.latestForDiscoveryf050e7df-c2c4-4601-83bb-0c9f3fdfda88

Files

Original bundle

Now showing 1 - 5 of 7
Thumbnail Image
Name:
AdultSox10(+)CardiomyocytesContribute_2019.pdf
Size:
5.79 MB
Format:
Adobe Portable Document Format
Description:
Download
Thumbnail Image
Name:
AdultSox10(+)CardiomyocytesContribute_2019-mmc1.pdf
Size:
14.79 MB
Format:
Adobe Portable Document Format
Description:
Download
Thumbnail Image
Name:
AdultSox10(+)CardiomyocytesContribute_2019-mmc2.xlsx
Size:
1.91 MB
Format:
Microsoft Excel XML
Description:
Download
Thumbnail Image
Name:
AdultSox10(+)CardiomyocytesContribute_2019-mmc3.xlsx
Size:
2.42 MB
Format:
Microsoft Excel XML
Description:
Download
Thumbnail Image
Name:
AdultSox10(+)CardiomyocytesContribute_2019-mmc4.xlsx
Size:
133.72 KB
Format:
Microsoft Excel XML
Description:
Download

Collections

Grupos de investigación