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Innate Immune Function of Mitochondrial Metabolism

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dc.contributor.authorSancho, David
dc.contributor.authorEnamorado, Michel
dc.contributor.authorGaraude, Johan
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderUnión Europea. Comisión Europea
dc.contributor.funderFondation ACTERIA (Acting on European Research in Immunology and Allergology)
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)
dc.contributor.funderFundación ProCNIC
dc.contributor.funderInstitut National de la Santé et de la Recherche Médicale (Francia)
dc.date.accessioned2017-10-20T10:23:11Z
dc.date.available2017-10-20T10:23:11Z
dc.date.issued2017
dc.description.abstractSensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing immune cell function. Mitochondria are at the core of metabolic adaptation to the changing environment. The close interaction between mitochondrial metabolism and immune signaling has emerged as a central regulator of innate sensing. Metabolic processes generate a constant flow of electrons that eventually end up in the mitochondrial electron transport chain (ETC). Two electron carriers and four respiratory complexes that can assemble as larger molecular supercomplexes compose the ETC in the mitochondrial inner membrane. While the meaning and biological relevance of such structural organization is a matter of passionate debates, recent data support that innate stimuli remodel the ETC. We will review the function of mitochondrial metabolism and ETC dynamics as innate rheostats that regulate signaling, transcription, and epigenetics to orchestrate innate immune responses.
dc.description.peerreviewedSí
dc.description.sponsorshipDS's laboratory is funded by the CNIC and grants from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Fund for Regional Development (FEDER) (SAF-2016-79040-R), the European Commission (635122-PROCROP H2020), the Fondation ACTERIA, and the European Research Council. The CNIC is supported by the MINECO and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). ME is the recipient of a CNIC International PhD Programme fellowship ``la Caixa-Severo Ochoa, 2013 Call (OSLC-CNIC-2013-04). JG's laboratory is funded by INSERM and a European FP7-Marie Curie Career Integration Grant (332881).
dc.format.volume8
dc.identifierISI:000400710100001
dc.identifier.citationFront Immunol. 2017; 8:527
dc.identifier.doi10.3389/fimmu.2017.00527
dc.identifier.issn1664-3224
dc.identifier.journalFrontiers in Immunology
dc.identifier.pubmedID28533780
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5117
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF-2016-79040-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/635122es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/332881/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2017.00527
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Inmunobiología
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInnate immune response
dc.subjectImmunometabolism
dc.subjectElectron transport chain
dc.subjectMitochondria
dc.subjectMacrophages
dc.subjectDendritic cells
dc.subjectCytokines
dc.subjectInflammation
dc.subjectNLRP3 INFLAMMASOME ACTIVATION
dc.subjectDENDRITIC CELL ACTIVATION
dc.subjectHOST-DEFENSE
dc.subjectMYCOBACTERIUM-TUBERCULOSIS
dc.subjectMACROPHAGE POLARIZATION
dc.subjectSUCCINATE-DEHYDROGENASE
dc.subjectALTERNATIVE ACTIVATION
dc.subjectPYRUVATE-DEHYDROGENASE
dc.subjectBACTERICIDAL ACTIVITY
dc.subjectTRAINED IMMUNITY
dc.titleInnate Immune Function of Mitochondrial Metabolism
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery58aa2591-8084-4500-bfe4-8f2c54e398e9
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