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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review

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dc.contributor.authorKoss-Mikolajczyk, Izabela
dc.contributor.authorTodorovic, Vanja
dc.contributor.authorSobajic, Sladjana
dc.contributor.authorMahajna, Jamal
dc.contributor.authorGeric, Marko
dc.contributor.authorTur, Josep A
dc.contributor.authorBartoszek, Agnieszka
dc.date.accessioned2024-09-18T06:43:47Z
dc.date.available2024-09-18T06:43:47Z
dc.date.issued2021-09
dc.description.abstractCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic-doxorubicin-as the oxidative stress- and cardiotoxicity-inducing agent.en
dc.description.sponsorshipThis research was supported by the project, Antioxidant Power Series as a tool for ra-tional design and assessment of health-promoting properties of functional food based on antiox-idant phytochemicals (application No 2014/14/A/ST4/00640) financed by National Science Centre, Poland in a programme MAESTRO 6. This cooperation was funded by the official funding agency for biomedical research of the Spanish government, Institute of Health Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the Euro-pean Regional Development Fund (Projects 11/01791, 14/00636 and 17/01827, Red Pred-imed-RETIC RD06/0045/1004, and CIBEROBN CB12/03/30038), and by the Ministry of Educa-tion, Science and Technological Development of Serbia (451-03-9/2021-14/200161).es_ES
dc.format.number18es_ES
dc.format.page10037es_ES
dc.format.volume22es_ES
dc.identifier.citationKoss-Mikolajczyk I, Todorovic V, Sobajic S, Mahajna J, Geric M, Tur JA, et al. Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review. Int J Mol Sci. 2021 Sep;22(18):10037.en
dc.identifier.doi10.3390/ijms221810037
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational Journal of Molecular Scienceses_ES
dc.identifier.otherhttps://hdl.handle.net/20.500.13003/19704
dc.identifier.pubmedID34576204es_ES
dc.identifier.puiL2013790682
dc.identifier.scopus2-s2.0-85115063451
dc.identifier.urihttps://hdl.handle.net/20.500.12105/23284
dc.identifier.wos699607500001
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.publisherversionhttps://dx.doi.org/10.3390/ijms221810037en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCardiotoxicity
dc.subjectCardioprotectants
dc.subjectPhytochemicals
dc.subjectAntioxidants
dc.subjectAnthracyclines
dc.subject.decsAnimales*
dc.subject.decsHumanos*
dc.subject.decsAntraciclinas*
dc.subject.decsFitoquímicos*
dc.subject.decsProductos Biológicos*
dc.subject.decsDoxorrubicina*
dc.subject.decsAntioxidantes*
dc.subject.meshAntioxidants*
dc.subject.meshPhytochemicals*
dc.subject.meshBiological Products*
dc.subject.meshDoxorubicin*
dc.subject.meshAnimals*
dc.subject.meshAnthracyclines*
dc.subject.meshHumans*
dc.titleNatural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Reviewen
dc.typereview articleen
dspace.entity.typePublication
relation.isPublisherOfPublication30293a55-0e53-431f-ae8c-14ab01127be9
relation.isPublisherOfPublication.latestForDiscovery30293a55-0e53-431f-ae8c-14ab01127be9

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