Publication: Changes in fluoroquinolone-resistant Streptococcus pneumoniae after 7-valent conjugate vaccination, Spain
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2009-06
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Centers for Disease Control and Prevention (CDC)
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Abstract
Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 microg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC >or=16 microg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006.
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Adult Anti-Bacterial Agents Bacterial Proteins Child Child, Preschool Ciprofloxacin Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Fluoroquinolones Genotype Heptavalent Pneumococcal Conjugate Vaccine Humans Microbial Sensitivity Tests Mutation Pneumococcal Vaccines Prevalence Sequence Analysis, DNA Serotyping Spain Streptococcal Infections Streptococcus pneumoniae Transformation, Bacterial Vaccination
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Emerg Infect Dis. 2009;15(6):905-11.