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Evolutionary convergence of sensory circuits in the pallium of amniotes.

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dc.contributor.authorRueda-Alaña, Eneritz
dc.contributor.authorSenovilla-Ganzo, Rodrigo
dc.contributor.authorGrillo, Marco
dc.contributor.authorVázquez, Enrique
dc.contributor.authorMarco-Salas, Sergio
dc.contributor.authorGallego-Flores, Tatiana
dc.contributor.authorOrdeñana-Manso, Aitor
dc.contributor.authorFtara, Artemis
dc.contributor.authorEscobar, Laura
dc.contributor.authorBenguría, Alberto
dc.contributor.authorQuintas, Ana
dc.contributor.authorDopazo, Ana
dc.contributor.authorRábano, Miriam
dc.contributor.authorVivanco, María dM
dc.contributor.authorAransay, Ana María
dc.contributor.authorGarrigos, Daniel
dc.contributor.authorToval, Ángel
dc.contributor.authorFerrán, José Luis
dc.contributor.authorNilsson, Mats
dc.contributor.authorEncinas-Pérez, Juan Manuel
dc.contributor.authorDe Pittà, Maurizio
dc.contributor.authorGarcía-Moreno, Fernando
dc.contributor.funderIkerbasque - Basque Foundation for Science
dc.contributor.funderMinisterio de Ciencia e Innovación (España)
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderAgencia Estatal de Investigación (España)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderFundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia
dc.date.accessioned2025-06-16T14:33:42Z
dc.date.available2025-06-16T14:33:42Z
dc.date.issued2025-01-02
dc.description.abstractThe amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko), and mammals (mouse). We reveal that neurons within these circuits' stations are generated at varying developmental times and brain regions across species and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons. Our research highlights developmental distinctions and functional similarities in the sensory circuit between birds and mammals, suggesting the convergence of high-order sensory processing across amniote lineages.
dc.description.peerreviewedSí
dc.description.tableofcontentsThis work was funded by a Ikerbasque Research Fellowship to F.G.-M.; Spanish Ministry grants MICINN PGC2018-096173-A-I00 and MICINN PID2021-125156NB-I00 F.G.-M; Basque Government grants PIBA 2020_1_0057 and PIBA_2022_1_0027 to F.G.-M.; EASI-GENOMICS 3rd TNA call PID14596 grant to F.G.-M.; Krembil Foundation Seed Fund FCC410015233 to M.D.P.; Spanish Ministry of Science, Innovation, and Universities (MCIU), State Research Agency (AEI), and European Regional Development Fund (FEDER), PGC2018-098229-B-100 to J.L.F.; Séneca Foundation 21903/PI/22 to J.L.F.; Chan Zuckerberg Initiative – Advised fund of Silicon Valley Community Foundation grant DAF2018-191929 to M.N.; Erling-Persson Family Foundation – A human developmental cell atlas grant to M.N.; Knut and Alice Wallenberg Foundation grant KAW 2018.0172 to M.N.; Swedish Research Council grant 2019-01238 to M.N.; Swedish Cancer Society – Cancerfonden grant CAN 2021/1726 to M.N.; Spanish Ministry grants MINECO/MICINN SAF-2015-70866-R and MICINN PID2019-104766RB to J.M.E.-P. Basque Government grant PIBA_2021_1_0018 to J.M.E.-P.; and a Fundacion Tatiana predoctoral fellowship to R. S.-G. CIC bioGUNE support was provided by the Department of Industry, Tourism and Trade of the Government of the Autonomous Community of the Basque Country (Emaitek and Elkartek Research Programs 2015-2023, KK-2020/00008), the Innovation Technology Department of the Bizkaia County, and by the Spanish Ministry of Science and Innovation grant MCIN/AEI/10.13039/501100011033 (PID2020-118464RB I00 and Severo Ochoa Excellence Accreditation CEX2021-001136-S) to A.M.A. and M.d.V.
dc.format.number6735
dc.format.volume387
dc.identifier.citationScience . 2025 Jan 2;387(6735):eadp3411.
dc.identifier.journalScience
dc.identifier.pubmedID39946453
dc.identifier.urihttps://hdl.handle.net/20.500.12105/26753
dc.language.isoeng
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PGC2018-096173-A-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2021-125156NB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIBA 2020_1_0057
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIBA_2022_1_0027
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PGC2018-098229-B-100
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MICINN PID2019-104766RB
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MINECO/MICINN SAF-2015-70866-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2020-118464RB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033/CEX2021-001136-S
dc.relation.publisherversionhttps://doi.org/10.1126/science.adp3411
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Unidades técnicas::Genómica
dc.rights.accessRightsopen access
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleEvolutionary convergence of sensory circuits in the pallium of amniotes.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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