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High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity

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dc.contributor.authorPerez-Garcia, Felipe
dc.contributor.authorMartin-Vicente, Maria
dc.contributor.authorRojas-García, Rosa Lía
dc.contributor.authorCastilla-García, Lucía
dc.contributor.authorMuñoz-Gómez, María José
dc.contributor.authorHervás Fernández, Irene
dc.contributor.authorGonzález Ventosa, Victoria
dc.contributor.authorVidal-Alcántara, Erick Joan
dc.contributor.authorCuadros-González, Juan
dc.contributor.authorBermejo-Martin, Jesús F
dc.contributor.authorResino, Salvador
dc.contributor.authorMartinez, Isidoro
dc.contributor.funderCanadian Institutes of Health Research
dc.contributor.funderGenome Atlantic (Canadá)es_ES
dc.contributor.funderLi Ka Shing Foundation
dc.contributor.funderDalhousie Medical Research Foundation
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias)
dc.contributor.funderJunta de Castilla y León (España)
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
dc.date.accessioned2024-02-06T07:32:43Z
dc.date.available2024-02-06T07:32:43Z
dc.date.issued2022-03-15
dc.description.abstractMucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2-infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by the Canadian Institutes of Health Research (grant number CIHR OV2-170357); Research Nova Scotia, Atlantic Genome/Genome Canada; Li-Ka Shing Foundation; Dalhousie Medical Research Foundation ( to J. F. B. M.); Instituto de Salud Carlos III (grant numbers COV20/00110 to J. F. B. M. and CIBERES 06/06/0028 to S. R.); Convocatoria extraordinaria y urgente de la Gerencia Regional de Salud de Castilla y León para la financiación de proyectos de investigación en enfermedad COVID-19 (grant number GRS COVID 53/A/20 to J. F. B. M.); and the Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (grant number CB21/13/00044 to S. R. and I. M.).es_ES
dc.format.number6es_ES
dc.format.page977-982es_ES
dc.format.volume225es_ES
dc.identifier.citationJ Infect Dis. 2022 Mar 15;225(6):977-982.es_ES
dc.identifier.doi10.1093/infdis/jiab604es_ES
dc.identifier.e-issn1537-6613es_ES
dc.identifier.journalThe Journal of infectious diseaseses_ES
dc.identifier.pubmedID34910814es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17490
dc.language.isoenges_ES
dc.publisherOxford University Press
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/COV20/00110es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CB21/13/00044es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/infdis/jiab604es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCCL5es_ES
dc.subjectCOVID-19es_ES
dc.subjectICUes_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectDeathes_ES
dc.subjectGene expressiones_ES
dc.subjectInnate immunityes_ES
dc.subjectNasopharynxes_ES
dc.subjectViral loades_ES
dc.subject.meshCOVID-19es_ES
dc.subject.meshSARS-CoV-2es_ES
dc.subject.meshChemokine CCL5es_ES
dc.subject.meshHumanses_ES
dc.subject.meshIntensive Care Unitses_ES
dc.subject.meshNasopharynxes_ES
dc.subject.meshRNA, Virales_ES
dc.subject.meshSeverity of Illness Indexes_ES
dc.subject.meshViral Loades_ES
dc.titleHigh SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severityes_ES
dc.typeresearch articlees_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
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