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Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

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InfectivityOfPostKala_2017.pdf (1.07 MB)
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URI: http://hdl.handle.net/20.500.12105/13961
DOI: 10.1093/cid/cix245

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2017-07-01

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Alvar, Jorge ISCIII ORCIDScopus Author ID

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Oxford University Press
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Abstract

We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.

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Control Leishmaniasis Post–kala-azar dermal leishmaniasis Xenodiagnosis

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Leishmania donovani Leishmaniasis, Visceral Adult Animals DNA, Protozoan Female Humans India Male Polymerase Chain Reaction Psychodidae Skin Xenodiagnosis Young Adult

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Bibliographic citation

Clin Infect Dis. 2017;65(1):150-153.

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Centro Nacional de Microbiología (CNM)

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https://doi.org/10.1093/cid/cix245

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journal article