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Viral Proteins that Enhance Membrane Permeability

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dc.contributor.authorGonzalez Portal, Maria Eugenia
dc.contributor.authorCarrasco, Luis
dc.contributor.funderFundación para la Investigación y la Prevención del Sida en España
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderDirección General de Investigación Científica y Técnica (España)
dc.date.accessioned2019-06-20T09:11:44Z
dc.date.available2019-06-20T09:11:44Z
dc.date.issued2005
dc.description.abstractThis chapter is devoted to reviewing some characteristics of membrane permeabilization by viral proteins. In addition, the methodology used to assay enhanced permeability in animal cells is described. Finally, the design of selective viral inhibitors based on the modification of cellular membranes during virus entry or at late times of infection is also discussed.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by grants from the Fundación para la Investigación y Prevención del SIDA en España (24291), Instituto de Salud Carlos III (01/0042) and the DGICYT PM99-0002. The authors also acknowledge the Fundación Ramón Areces for an institutional grant awarded to the Centro de Biología Molecular "Severo Ochoa"
dc.description.tableofcontents1. Introduction 2. Measuring alterations in membrane permeability 2.1. The hygromycin B test 2.2. Entry of macromolecules into virus-infected cells 2.3. Other assays to test the entry or exit of macromolecules from virus-infected cells 3. Viral proteins that modify permeability 3.1. Viroporins 3.2. Viral glycoproteins that modify membrane permeability 4. Membrane permeabilization and drug design 4.1. Antibiotics and toxins that selectively enter virus-infected cells 4.2. Viroporin inhibitors 4.3. Antiviral agents that interfere with viral glycoproteins 5. Acknowledgments References Figureses_ES
dc.format.page90es_ES
dc.format.volume1es_ES
dc.identifier.citationGonzález M.E., Carrasco L. (2005) Viral Proteins that Enhance Membrane Permeability. In: Fischer W.B. (eds) Viral Membrane Proteins: Structure, Function, and Drug Design. Protein Reviews, vol 1. Springer, Boston, MAes_ES
dc.identifier.doi10.1007/0-387-28146-0_6es_ES
dc.identifier.isbn978-0-387-28146-9
dc.identifier.isbn978-0-306-48495-7
dc.identifier.issn978-0-306-48495-7es_ES
dc.identifier.journalProtein Reviews, Vol Ies_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7792
dc.language.isoenges_ES
dc.publisherKluwer Academic Publisherses_ES
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dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/01/0042es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PM99-0002es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/24291es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/0-387-28146-0_6es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectViroporinses_ES
dc.subjectViral Glycoproteinses_ES
dc.subjectMembrane permeabilizationes_ES
dc.subjectAntiviral agentses_ES
dc.subjectViroporin inhibitorses_ES
dc.subjectBiological assayses_ES
dc.subjectHIV-1es_ES
dc.subjectPolioviruses_ES
dc.subjectHIV-1 gp41es_ES
dc.subject.meshVirus Releasees_ES
dc.subject.meshCell Membrane Permeabilityes_ES
dc.subject.meshCytopathogenic Effect, Virales_ES
dc.subject.meshModels, Biologicales_ES
dc.subject.meshMembrane Proteinses_ES
dc.subject.meshMembrane Glycoproteinses_ES
dc.subject.meshToxins, Biologicales_ES
dc.titleViral Proteins that Enhance Membrane Permeabilityes_ES
dc.title.alternativeIn: Fischer W.B. (eds) Viral Membrane Proteins: Structure, Function, and Drug Design.es_ES
dc.typebook partes_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationbd55b7e0-7523-4dc6-83da-c9edd512d078
relation.isAuthorOfPublication.latestForDiscoverybd55b7e0-7523-4dc6-83da-c9edd512d078

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