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HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity

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dc.contributor.authorPernas, Maria
dc.contributor.authorSanchez-Merino, Victor
dc.contributor.authorCasado, Concepcion
dc.contributor.authorMerino-Mansilla, Alberto
dc.contributor.authorOlivares, Isabel
dc.contributor.authorYuste-Herranz, Maria Eloisa
dc.contributor.authorLopez-Galindez, Luis Cecilio
dc.contributor.funderFundación para la Investigación y la Prevención del Sida en España
dc.contributor.funderRed de Investigación Cooperativa en Investigación en Sida (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)
dc.date.accessioned2018-12-21T11:00:47Z
dc.date.available2018-12-21T11:00:47Z
dc.date.issued2015-08-10
dc.description.abstractThis study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipWork in CNM is supported by grants from Fundacion para la Investigación del Sida en España (www.fipse.es) and (PI 13/02269) Fondo de Investigación Sanitaria (ISCIII) (www.isciii.es) to CL. Red de Investigación en SIDA www.retic-ris.net to CL. A grant RD12/0017/0036 to CL as part of the Plan Nacional R D+I and cofinanced by ISCIII (www.isciii.es) - Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). CL IDIBAPS work was supported by a grant (RYC-2007-00788) to EY from the Ministerio de Ciencia y Tecnologia www.micinn.es, a grant (PS09/01459) to EY from the Fondo de Investigaciones Sanitarias (ISCIII) (www.isciii.es).es_ES
dc.format.number8es_ES
dc.format.pagee0134054es_ES
dc.format.volume10es_ES
dc.identifier.citationPLoS One. 2015 Aug 10;10(8):e0134054es_ES
dc.identifier.doi10.1371/journal.pone.0134054es_ES
dc.identifier.e-issn1932-6203es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.journalPloS onees_ES
dc.identifier.pubmedID26258485es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6929
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS)
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI 13/02269es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0017/0036es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RYC-2007-00788es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01459es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0134054es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAntibodies, Neutralizinges_ES
dc.subject.meshEntropyes_ES
dc.subject.meshFollow-Up Studieses_ES
dc.subject.meshGenetic Variationes_ES
dc.subject.meshHIV Antibodieses_ES
dc.subject.meshHIV Infectionses_ES
dc.subject.meshHIV-1es_ES
dc.subject.meshHumanses_ES
dc.subject.meshNeutralization Testses_ES
dc.subject.meshPhylogenyes_ES
dc.subject.meshViral Loades_ES
dc.subject.meshViremiaes_ES
dc.subject.meshHIV Long-Term Survivorses_ES
dc.titleHIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activityes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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