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A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.

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dc.contributor.authorBueno, Clara
dc.contributor.authorTorres-Ruiz, Raul
dc.contributor.authorVelasco-Hernandez, Talia
dc.contributor.authorMolina, Oscar
dc.contributor.authorPetazzi, Paolo
dc.contributor.authorMartinez, Alba
dc.contributor.authorRodriguez, Virginia
dc.contributor.authorVinyoles, Meritxell
dc.contributor.authorCantilena, Sandra
dc.contributor.authorWilliams, Owen
dc.contributor.authorVega-Garcia, Nerea
dc.contributor.authorRodriguez Perales, Sandra
dc.contributor.authorSegovia, Jose C
dc.contributor.authorQuintana-Bustamante, Oscar
dc.contributor.authorRoy, Anindita
dc.contributor.authorMeyer, Claus
dc.contributor.authorMarschalek, Rolf
dc.contributor.authorSmith, Alastair L
dc.contributor.authorMilne, Thomas A
dc.contributor.authorFraga, Mario F
dc.contributor.authorTejedor, Juan Ramón
dc.contributor.authorMenéndez, Pablo
dc.contributor.funderUK Research & Innovation (UKRI)
dc.contributor.funderMedical Research Council UK (MRC)
dc.date.accessioned2025-01-27T10:31:57Z
dc.date.available2025-01-27T10:31:57Z
dc.date.issued2023-11-16
dc.description.abstractCellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.
dc.description.peerreviewedSí
dc.format.number20
dc.format.page1752-1756
dc.format.volume142
dc.identifier.citationBlood . 2023 Nov 16;142(20):1752-1756.
dc.identifier.journalBlood
dc.identifier.pubmedID37756522
dc.identifier.urihttps://hdl.handle.net/20.500.12105/26144
dc.language.isoeng
dc.publisherElsevier
dc.relation.publisherversionhttps:// doi: 10.1182/blood.2023020858.
dc.repisalud.institucionCNIO
dc.repisalud.orgCNIOCNIO::Unidades técnicas::Unidad de Citogenética Molecular
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectACUTE LEUKEMIAS
dc.subjectRECOMBINOME
dc.subjectBREAKPOINTS
dc.subjectBIOLOGY
dc.subjectMLL-AF4
dc.titleA human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.
dc.typeletter to the editor
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication6c54780c-068e-41c2-9f5d-ec932cd52d04
relation.isAuthorOfPublicationcac6c6e2-06a9-4548-b216-3d7d32ed6b6e
relation.isAuthorOfPublication.latestForDiscoverycac6c6e2-06a9-4548-b216-3d7d32ed6b6e

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