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Imported Human West Nile Virus Lineage 2 Infection in Spain: Neurological and Gastrointestinal Complications

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dc.contributor.authorVelasco, María
dc.contributor.authorSánchez-Seco, María Paz
dc.contributor.authorCampelo, Carolina
dc.contributor.authorDe Ory, Fernando de
dc.contributor.authorMartin, Oriol
dc.contributor.authorHerrero-Romero, Laura
dc.contributor.authorSalmerón Béliz, Octavio J
dc.contributor.authorMinguito, Teodora
dc.contributor.authorCampos, Mª Carmen
dc.contributor.authorMolero-Sanz, Francisca
dc.contributor.authorAlgora, Alejandro
dc.contributor.authorVazquez, Ana
dc.contributor.funderInstituto de Salud Carlos III
dc.date.accessioned2020-02-19T08:16:41Z
dc.date.available2020-02-19T08:16:41Z
dc.date.issued2020-01-29
dc.description.abstractWe report the first human case of West Nile virus (WNV) lineage 2 infection imported to Spain by a traveler returning from Romania. Serum, cerebrospinal fluid and urine samples were analyzed and West Nile virus infection was identified by PCR and serological tests. The patient developed fever, diarrhea and neurological symptoms, accompanied by mild pancreatitis, described previously in very few cases as a complication of WNV infection and by alithiasic cholecystitis. Viral RNA was detected in urine until 30 days after the onset of symptoms and neutralizing antibodies were detected at very low titers. The phylogenetic analysis in a fragment of the NS5 gene of the virus showed a homology with sequences from WNV lineage 2 belonging to the monophyletic Central/Southern European group.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was partially funded by the Instituto de Salud Carlos III Projects “PI14CIII/00014” and “PI19CIII_00014”.es_ES
dc.format.number2es_ES
dc.format.page156es_ES
dc.format.volume12es_ES
dc.identifier.citationViruses. 2020 Jan 29;12(2). pii: E156.es_ES
dc.identifier.doi10.3390/v12020156es_ES
dc.identifier.e-issn1999-4915es_ES
dc.identifier.issn1999-4915es_ES
dc.identifier.journalViruseses_ES
dc.identifier.pubmedID32013149es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9113
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14CIII/00014es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI19CIII_00014es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/v12020156es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSpaines_ES
dc.subjectWest Nile virus lineage 2es_ES
dc.subjectDigestive complicationses_ES
dc.subjectHumanes_ES
dc.subjectNeurological symptomses_ES
dc.titleImported Human West Nile Virus Lineage 2 Infection in Spain: Neurological and Gastrointestinal Complicationses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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