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Leptin as a key regulator of the adipose organ

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dc.contributor.authorPicó, Catalina
dc.contributor.authorPalou, Mariona
dc.contributor.authorAmadora Pomar, Catalina
dc.contributor.authorRodriguez, Ana María
dc.contributor.authorPalou, Andreu
dc.date.accessioned2024-10-04T13:46:17Z
dc.date.available2024-10-04T13:46:17Z
dc.date.issued2022-02
dc.description.abstractLeptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin is also produced by other tissues, such as the stomach, placenta, and mammary gland. Altogether, leptin exerts a broad spectrum of short, medium, and long-term regulatory actions at the central and peripheral levels, including metabolic programming effects that condition the proper development and function of the adipose organ, which are relevant for its main role in energy homeostasis. Comprehending how leptin regulates adipose tissue may provide important clues to understand the pathophysiology of obesity and related diseases, such as type 2 diabetes, as well as its prevention and treatment. This review focuses on the physiological and long-lasting regulatory effects of leptin on adipose tissue, the mechanisms and pathways involved, its main outcomes on whole-body physiological homeostasis, and its consequences on chronic diseases.en
dc.description.sponsorshipGrant PGC2018-097436-B-I00 (MCIU/AEI/FEDER, UE).es_ES
dc.format.number1es_ES
dc.format.page13-30es_ES
dc.format.volume23es_ES
dc.identifier.citationPico C, Palou M, Pomar CA, Rodriguez AM, Palou A. Leptin as a key regulator of the adipose organ. Rev Endocr Metab Disord. 2022 Feb;23(1):13-30.en
dc.identifier.doi10.1007/s11154-021-09687-5
dc.identifier.e-issn1573-2606es_ES
dc.identifier.issn1389-9155
dc.identifier.journalReviews in Endocrine & Metabolic Disorderses_ES
dc.identifier.otherhttps://hdl.handle.net/20.500.13003/19665
dc.identifier.pubmedID34523036es_ES
dc.identifier.puiL2013691275
dc.identifier.scopus2-s2.0-85114853660
dc.identifier.urihttps://hdl.handle.net/20.500.12105/23470
dc.identifier.wos695807300001
dc.language.isoengen
dc.publisherSpringer
dc.relation.publisherversionhttps://doi.org/10.1007/s11154-021-09687-5en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLeptin
dc.subjectAdipose organ
dc.subjectAdiposity
dc.subjectEnergy homeostasis
dc.subjectMetabolic programming
dc.subjectDevelopment
dc.subject.decsTejido Adiposo*
dc.subject.decsHumanos*
dc.subject.decsObesidad*
dc.subject.decsDiabetes Mellitus Tipo 2*
dc.subject.decsHomeostasis*
dc.subject.decsLeptina*
dc.subject.meshDiabetes Mellitus, Type 2*
dc.subject.meshHomeostasis*
dc.subject.meshLeptin*
dc.subject.meshAdipose Tissue*
dc.subject.meshHumans*
dc.subject.meshObesity*
dc.titleLeptin as a key regulator of the adipose organen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublication8d558850-2ef2-4d1e-b0e1-4e5591ab6288
relation.isPublisherOfPublication.latestForDiscovery8d558850-2ef2-4d1e-b0e1-4e5591ab6288

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