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Boosting NAD(+) for the prevention and treatment of liver cancer.

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dc.contributor.authorDjouder, Nabil
dc.contributor.funderAssociation for International Cancer Researches_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)
dc.contributor.funderEuropean Foundation for the Study of Diabetes
dc.date.accessioned2024-02-08T12:55:57Z
dc.date.available2024-02-08T12:55:57Z
dc.date.issued2015
dc.description.abstractHepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide yet has limited therapeutic options. We recently demonstrated that inhibition of de novo nicotinamide adenine dinucleotide (NAD(+)) synthesis is responsible for DNA damage, thereby initiating hepatocarcinogenesis. We propose that boosting NAD(+) levels might be used as a prophylactic or therapeutic approach in HCC.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThisworkwassupportedbytheSpanishMinistryofEconomyandCompetitiveness(SAF2010-18518), the Association forInternational Cancer Research AICR-UK(11-0242), CNIO (BC1104-08) and theEuropeanFoundationfortheStudyofDia-betes(EFSD).es_ES
dc.format.number4es_ES
dc.format.pagee1001199es_ES
dc.format.volume2es_ES
dc.identifier.citationMol Cell Oncol . 2015 Feb 3;2(4):e1001199.es_ES
dc.identifier.doi10.1080/23723556.2014.1001199es_ES
dc.identifier.issn2372-3556es_ES
dc.identifier.journalMolecular & cellular oncologyes_ES
dc.identifier.pubmedID27308492es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17548
dc.language.isoenges_ES
dc.publisherTaylor & Francis
dc.relation.publisherversionhttps://doi.org/ 10.1371/10.1080/23723556.2014.1001199.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Factores de Crecimiento, Nutrientes y Cánceres_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleBoosting NAD(+) for the prevention and treatment of liver cancer.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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