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Enterocytozoon bieneusi (Microsporidia): Identification of novel genotypes and evidence of transmission between sympatric wild boars (Sus scrofa ferus) and Iberian pigs (Sus scrofa domesticus) in Southern Spain

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dc.contributor.authorDashti, Alejandro
dc.contributor.authorRivero-Juarez, Antonio
dc.contributor.authorSantín, Mónica
dc.contributor.authorLópez-López, Pedro
dc.contributor.authorCaballero-Gómez, Javier
dc.contributor.authorFrías-Casas, Mario
dc.contributor.authorKöster, Pamela Carolina
dc.contributor.authorBailo-Barroso, Begoña
dc.contributor.authorCalero-Bernal, Rafael
dc.contributor.authorBriz, Veronica
dc.contributor.authorCarmena, David
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.date.accessioned2020-06-24T07:16:40Z
dc.date.available2020-06-24T07:16:40Z
dc.date.issued2020
dc.description.abstractMicrosporidia is a phylum of obligate emergent intracellular protist-like fungi pathogens that infect a broad range of hosts including vertebrates and invertebrates. Enterocytozoon bieneusi is the most common cause of microsporidiosis in humans, affecting primarily immunosuppressed patients but also reported in immunocompetent individuals. Epidemiological information on the presence and molecular diversity of E. bieneusi in livestock and wildlife in Spain is limited. Therefore, the occurrence of this microsporidia was investigated in sympatric extensively reared Iberian pigs (n = 186) and free ranging wild boars (n = 142) in the province of Córdoba, Southern Spain. Forty-two Iberian pigs (22.6%) and three wild boars (2.1%) were found E. bieneusi positive by PCR. In Iberian pigs, occurrence of E. bieneusi was significantly higher in sows than in fattening pigs (31.6% vs. 11.4%; p = .001). Five genotypes were identified in Iberian pigs, four previously reported (EbpA, PigEb4, O, Pig HN-II) and a novel genotype (named PigSpEb1), while only two genotypes were identified in wild boars, EbpA and novel genotype PigSpEb1. All five genotypes identified belong to Group 1 suggesting zoonotic potential. This study constitutes the first report on the occurrence and molecular characterization of E. bieneusi in Iberian pigs and wild boars. The identification of two genotypes with zoonotic potential in sympatric Iberian pigs and wild boars suggests that E. bieneusi can be potentially transmitted between those two hosts, but also implies that they may act as natural sources of microsporidia infection to other hosts including humans.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis study was funded by the Health Institute Carlos III (ISCIII), Ministry of Economy and Competitiveness (Spain), under project PI16CIII/00024. Antonio Rivero‐Juarez is the recipient of a Miguel Servet Research Contract by the Ministry of Science, Innovation and Universities (Spain, CP18/00111).Mario Frías‐Casas is the recipient of a Sara Borrell contract by the Ministerio de Ciencia, Promoción y Universidades of Spain (CD18/00091). Javier Caballero‐Gómez is supported by an FPU grant from the Spanish Ministry of Education,Culture and Sport (FPU17/01319).es_ES
dc.identifier.citationTransbound Emerg Dis. 2020 Nov;67(6):2869-2880.es_ES
dc.identifier.doi10.1111/tbed.13658es_ES
dc.identifier.e-issn1865-1682es_ES
dc.identifier.journalTransboundary and emerging diseaseses_ES
dc.identifier.pubmedID32500974es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10546
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/ISCIII 2016 Modalidad Proyectos de Investigacion en Salud Intramurales. (2016)/PI16CIII/00024
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleEnterocytozoon bieneusi (Microsporidia): Identification of novel genotypes and evidence of transmission between sympatric wild boars (Sus scrofa ferus) and Iberian pigs (Sus scrofa domesticus) in Southern Spaines_ES
dc.typeresearch articlees_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
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