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MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice

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dc.contributor.authorBello-Arroyo, Elisabet
dc.contributor.authorRoque, Helio
dc.contributor.authorMarcos, Alberto
dc.contributor.authorOrihuel, Javier
dc.contributor.authorHiguera-Matas, Alejandro
dc.contributor.authorDesco, Manuel
dc.contributor.authorCaiolfa, Valeria R
dc.contributor.authorAmbrosio, Emilio
dc.contributor.authorLara-Pezzi, Enrique
dc.contributor.authorGomez-Gaviro, Maria Victoria
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderFundación ProCNIC
dc.date.accessioned2018-10-26T07:59:25Z
dc.date.available2018-10-26T07:59:25Z
dc.date.issued2018
dc.description.abstractAnimal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online.
dc.description.peerreviewedSí
dc.description.sponsorshipThis study was funded by a grant from the Spanish Ministerio de Ciencia, Innovacion y Universidades to EL-P (SAF2015-65722-R), and grants from the Instituto de Salud Carlos III (RIC, RD12/0042/0057) and the Autonomous Region of Madrid (BRADE S2013/ICE-2958) to MD, as well as by Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM). This work was also supported by the Plan Estatal de I+D+I 2013-2016-European Regional Development Fund (FEDER) ``A way of making Europe,'' Spain. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministerio de Ciencia, Innovacion y Universidades and by the Pro-CNIC Foundation and is a Severo Ochoa Centre of Excellence (MINECO award SEV-2015-0505).
dc.format.volume12
dc.identifierISI:000444046500001
dc.identifier.citationFront Behav Neurosci. 2018; 12:201
dc.identifier.doi10.3389/fnbeh.2018.00201
dc.identifier.issn1662-5153
dc.identifier.journalFrontiers in Behavioral Neuroscience
dc.identifier.pubmedID30245618
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6534
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.publisherversionhttps://doi.org/10.3389/fnbeh.2018.00201
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiaca
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzada
dc.repisalud.orgCNICCNIC::Unidades técnicas::Microscopía
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbehavioral tests
dc.subjectRodents
dc.subjectOpen source
dc.subjectImageJ
dc.subjectSemi-automated analysis
dc.subjectOPEN-FIELD TEST
dc.subjectALZHEIMERS-DISEASE
dc.subjectRODENTS
dc.subjectMAZE
dc.subjectANIMALS
dc.subjectMODELS
dc.subjectSYSTEM
dc.subjectFEAR
dc.titleMouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery1eb0420a-65c8-4764-a47b-8f02c213b033

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