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Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.

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dc.contributor.authorNavarro-Lleó, Noemi
dc.contributor.authorAznar-Córdoba, Silvia
dc.contributor.authorAsensio-Cob, Dunia
dc.contributor.authorLuque, Daniel
dc.contributor.authorRodríguez, Javier M
dc.contributor.authorGozalbo-Rovira, Roberto
dc.contributor.authorAlcaraz-Soriano, María Jesús
dc.contributor.authorCárcamo-Calvo, Roberto
dc.contributor.authorRodríguez-Díaz, Jesús
dc.contributor.authorBuesa, Javier
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderGeneralitat Valenciana (España)
dc.date.accessioned2026-05-08T20:48:05Z
dc.date.available2026-05-08T20:48:05Z
dc.date.issued2025-08
dc.description.abstractSpecies A rotavirus (RVA) is a major cause of acute gastroenteritis in children. However, three other rotavirus species (RVB, RVC, and RVH) are also able to infect humans. It has been suggested that vaccination against RVA could facilitate an increase of non-A rotavirus infections. We investigated the antibody prevalence against RVA, RVB, RVC, and RVH in 420 human sera collected between 2020 and 2022 from different age groups in Valencia (Spain). Antibody prevalence rates to RVA, RVB, RVC, and RVH were 79.3%, 17.9%, 18.8%, and 14.5%, respectively. Antibody titers against RVA remained consistent across the different age groups, and RVB showed low titers except in younger individuals. RVC-specific antibodies peaked in children 5-10 years of age, whereas RVH exhibited the highest titers in the elderly. The detection of antibodies against non-A rotaviruses in humans in Spain, for the first time against RVB and RVH, highlights the need for their surveillance.
dc.description.peerreviewedSí
dc.description.sponsorshipThis study was supported by grant PI20/00801 from the Carlos III Health Institute, Spanish Ministry of Science and Innovation. We also acknowledge the Generalitat Valenciana for its financial support by grant ACIF/2020/076 to N.N.-L.
dc.format.number8
dc.format.pagee70542
dc.format.volume97
dc.identifier.citationNavarro-Lleó N, Aznar-Córdoba S, Asensio-Cob D, Luque D, Rodríguez JM, Gozalbo-Rovira R, Alcaraz-Soriano MJ, Cárcamo-Calvo R, Rodríguez-Díaz J, Buesa J. Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain. J Med Virol. 2025 Aug;97(8):e70542. doi: 10.1002/jmv.70542. PMID: 40751697; PMCID: PMC12317683.
dc.identifier.doi10.1002/jmv.70542
dc.identifier.journalJournal of Medical Virology
dc.identifier.pubmedID40751697
dc.identifier.urihttps://hdl.handle.net/20.500.12105/27457
dc.language.isoeng
dc.publisherWiley
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00801/ES/INTERACCIONES VIRUS-HUESPED EN ROTAVIRUS DE ESPECIES NO A Y SU PREVALENCIA EN INFECCIONES HUMANAS/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Generalitat Valenciana//ACIF%2F2020%2F076///
dc.relation.publisherversionhttps://doi.org/10.1002/jmv.70542
dc.repisalud.centroISCIII::Centro Nacional de Microbiología (CNM)
dc.repisalud.centroISCIII::Unidades Centrales Científico-Técnicas (UCCTs)
dc.repisalud.institucionISCIII
dc.repisalud.instituteIIS::INCLIVA - Instituto de Investigación Sanitaria Fundación para la Investigación del Hospital Clínico de Valencia (C. Valenciana)
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectVP2
dc.subjectVP6
dc.subjectAntibodies
dc.subjectNon‐A rotaviruses
dc.subjectSeroepidemiology
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntibodies, Viral
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshGastroenteritis
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRotavirus Infections
dc.subject.meshRotavirus
dc.subject.meshSeroepidemiologic Studies
dc.subject.meshSpain
dc.subject.meshYoung Adult
dc.titleSeroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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