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Genetic characterization of fluoroquinolone-resistant Streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasis

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dc.contributor.authorde la Campa, Adela G
dc.contributor.authorFerrandiz-Avellano, Maria-Jose
dc.contributor.authorTubau, Fe
dc.contributor.authorPallarés, Román
dc.contributor.authorManresa, Federico
dc.contributor.authorLiñares, Josefina
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)
dc.date.accessioned2019-08-13T12:07:13Z
dc.date.available2019-08-13T12:07:13Z
dc.date.issued2003-04
dc.description.abstractFive Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.es_ES
dc.description.sponsorshipWe thank A. Fenoll, Spanish Pneumococcus Reference Laboratory (Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid), for checking serotypes. We thank M. A. Dominguez for performing the PFGE analysis and critically reading the manuscript. This work was supported by grants 00/0258 and 01/1267 from the Fondo de Investigación Sanitaria and by grant BIO2002-01398 from the Ministerio de Ciencia y Tecnología.es_ES
dc.format.number4es_ES
dc.format.page1419-22es_ES
dc.format.volume47es_ES
dc.identifier.citationAntimicrob Agents Chemother. 2003 Apr;47(4):1419-22.es_ES
dc.identifier.doi10.1128/aac.47.4.1419-1422.2003es_ES
dc.identifier.issn0066-4804es_ES
dc.identifier.journalAntimicrobial agents and chemotherapyes_ES
dc.identifier.pubmedID12654682es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/8235
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiology (ASM)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/00/0258es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/01/1267es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2002-01398es_ES
dc.relation.publisherversionhttps://doi.org/10.1128/AAC.47.4.1419-1422.2003es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnti-Infective Agentses_ES
dc.subject.meshBronchiectasises_ES
dc.subject.meshCiprofloxacines_ES
dc.subject.meshDrug Resistance, Bacteriales_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshStreptococcus pneumoniaees_ES
dc.subject.meshMutationes_ES
dc.titleGenetic characterization of fluoroquinolone-resistant Streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasises_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication922840af-6109-45f8-a77c-8897bc451446
relation.isAuthorOfPublication9a727424-6bd8-4106-ba1b-a9167268d3f8
relation.isAuthorOfPublication.latestForDiscovery922840af-6109-45f8-a77c-8897bc451446

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