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Role of Trypanosoma cruzi autoreactive T cells in the generation of cardiac pathology.

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Role of Trypanosoma cruzi_Ann N Y Acad Sci_2007_fig.pdf (48.41 KB)
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URI: http://hdl.handle.net/20.500.12105/17402
ISSN: 0077-8923
DOI: 10.1196/annals.1381.046
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2007-06
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Wiley
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Chagas disease, caused by Trypanosoma cruzi, affects several million people in Central and South America. About 30% of chronic patients develop cardiomyopathy probably caused by parasite persistence and/or autoimmunity. While several cross-reactive antibodies generated during mammal T. cruzi infection have been described, very few cross-reactive T cells have been identified. We performed adoptive transfer experiments of T cells isolated from chronically infected mice. The results showed the generation of cardiac pathology in the absence of parasites. We also transferred cross-reactive SAPA-specific T cells and observed unspecific alterations in heart repolarization, cardiac inflammatory infiltration, and tissue damage.
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Animals Autoimmunity Chagas Disease Epitopes Humans Molecular Mimicry T-Lymphocytes Trypanosoma cruzi
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Ann N Y Acad Sci. 2007 Jun:1107:434-44.
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10.1196/annals.1381.046
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journal article