Publication:
Direct and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spain

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dc.contributor.authorMonge, Susana
dc.contributor.authorOlmedo, Carmen
dc.contributor.authorAlejos, Belén
dc.contributor.authorLapeña, María Fé
dc.contributor.authorSierra, María José
dc.contributor.authorLimia, Aurora
dc.contributor.authorCOVID-19 Registries Study Group2
dc.contributor.authorMazagatos, Clara
dc.contributor.authorLarrauri, Amparo
dc.date.accessioned2023-02-07T10:56:28Z
dc.date.available2023-02-07T10:56:28Z
dc.date.issued2021-10
dc.description.abstractWe conducted a registries-based cohort study of long-term care facility residents >65 years of age offered vaccination against severe acute respiratory syndrome coronavirus 2 before March 10, 2021, in Spain. Risk for infection in vaccinated and nonvaccinated persons was compared with risk in the same persons in a period before the vaccination campaign, adjusted by daily-varying incidence and reproduction number. We selected 299,209 persons; 99.0% had >1 dose, 92.6% had 2 doses, and 99.8% of vaccines were Pfizer/BioNTech (BNT162b2). For vaccinated persons with no previous infection, vaccine effectiveness was 81.8% (95% CI 81.0%-82.7%), and 11.6 (95% CI 11.3-11.9) cases were prevented per 10,000 vaccinated/day. In those with previous infection, effectiveness was 56.8% (95% CI 47.1%-67.7%). In nonvaccinated residents with no previous infection, risk decreased by up to 81.4% (95% CI 73.3%-90.3%). Our results confirm vaccine effectiveness in this population and suggest indirect protection in nonvaccinated persons.es_ES
dc.description.peerreviewedSíes_ES
dc.format.number10es_ES
dc.format.page2595-2603es_ES
dc.format.volume27es_ES
dc.identifier.citationEmerg Infect Dis. 2021 Oct;27(10):2595-2603.es_ES
dc.identifier.doi10.3201/eid2710.211184es_ES
dc.identifier.e-issn1080-6059es_ES
dc.identifier.journalEmerging infectious diseaseses_ES
dc.identifier.pubmedID34314670es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15459
dc.language.isoenges_ES
dc.publisherCenters for Disease Control and Prevention (CDC)es_ES
dc.relation.publisherversionhttps://doi.org/10.3201/eid2710.211184es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectSpaines_ES
dc.subjectCoronavirus diseasees_ES
dc.subjectElderlyes_ES
dc.subjectIndirect effectses_ES
dc.subjectLong-term care facilitieses_ES
dc.subjectRespiratory infectionses_ES
dc.subjectSevere acute respiratory syndrome coronavirus 2es_ES
dc.subjectTransmissibilityes_ES
dc.subjectVaccinationes_ES
dc.subjectVaccine effectivenesses_ES
dc.subjectViruseses_ES
dc.subjectZoonoseses_ES
dc.subject.meshCOVID-19es_ES
dc.subject.meshSARS-CoV-2es_ES
dc.subject.meshBNT162 Vaccinees_ES
dc.subject.meshCOVID-19 Vaccineses_ES
dc.subject.meshCohort Studieses_ES
dc.subject.meshHumanses_ES
dc.subject.meshLong-Term Carees_ES
dc.subject.meshRNA, Messengeres_ES
dc.subject.meshSpaines_ES
dc.subject.meshVaccinationes_ES
dc.titleDirect and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spaines_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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