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Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells

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dc.contributor.authorCalzada-Fraile, Diego
dc.contributor.authorIborra, Salvador
dc.contributor.authorRamírez-Huesca, Marta
dc.contributor.authorJorge, Inmaculada
dc.contributor.authorDotta, Enrico
dc.contributor.authorHernández-García, Elena
dc.contributor.authorMartín-Cófreces, Noa
dc.contributor.authorNistal-Villán, Estanislao
dc.contributor.authorVeiga, Esteban
dc.contributor.authorVazquez, Jesus
dc.contributor.authorPasqual, Giulia
dc.contributor.authorSánchez-Madrid, Francisco
dc.date.accessioned2023-11-21T12:05:50Z
dc.date.available2023-11-21T12:05:50Z
dc.date.issued2023
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Science and Innovation (grants PID2020-120412RB-I00, PDC2021-121797-I00, PGC2018- 097019-BI00, PID2021-122348NB-I00, PLEC2022-009235, PLEC2022- 009298, PID2021-125415OB-I00, and PID2019-105761RB-I00); Comunidad de Madrid (INTEGRAMUNE, P2022/BMD7209 and IMMUNO-VAR, P2022/BMD-7333); Ramón Areces Foundation “Ciencias de la Vida y la Salud” (XIX Concurso-2018); “la Caixa” Banking Foundation (grants HR17-00016, HR17-00247, and HR22-00253); ProteoRed from Instituto de Salud Carlos III (PT17/0019/0003- ISCIII-SGEFI / ERDF); CIBER Cardiovascular (CB16/11/00272, CB16/11/00277); Agencia Estatal de Investigación (AEI); Fondo de Investigació n Sanitaria del Instituto de Salud Carlos III; co-funding by Fondo Europeo de Desarrollo Regional (FEDER); and European Research Council Starting Grant SYNVIVO 853179. D.C.-F. is supported by an INPhINIT Retaining Fellowship from “la Caixa” Foundation (LCF/BQ/DR19/11740010). S.I. is supported by a RYC-2016- 19463 fellowship. E.H. is supported by an FPI fellowship (PRE2019- 087509). We thank Miguel Vicente-Manzanares for critically reading the manuscript. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). The QIAGEN IPA software was used to create Figs. 3a and 5a.es_ES
dc.format.number1es_ES
dc.format.volume14es_ES
dc.identifier.citationNat Commun. 2023 Oct 25;14(1):6772.es_ES
dc.identifier.doi10.1038/s41467-023-42480-3es_ES
dc.identifier.e-issn2041-1723es_ES
dc.identifier.journalNature Communicationses_ES
dc.identifier.pubmedID37880206es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16706
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.publisherversion10.1038/s41467-023-42480-3es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovasculares_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleImmune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cellses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicatione2541003-e1a6-464d-8b2e-285ada6c18c4
relation.isAuthorOfPublication692b9503-3e2f-4789-8903-521fdd0115f3
relation.isAuthorOfPublication9743763b-919c-4fa9-a53c-57c41be5e0ac
relation.isAuthorOfPublication.latestForDiscoverye2541003-e1a6-464d-8b2e-285ada6c18c4

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