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MicroRNAs in T Cell-Immunotherapy.

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dc.contributor.authorDosil, Sara G
dc.contributor.authorRodríguez-Galán, Ana
dc.contributor.authorSánchez-Madrid, Francisco
dc.contributor.authorFernández-Messina, Lola
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderComunidad de Madrid (España)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderAsociación Española Contra el Cánceres_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)es_ES
dc.date.accessioned2023-09-04T14:16:08Z
dc.date.available2023-09-04T14:16:08Z
dc.date.issued2022-12-23
dc.description.abstractMicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis manuscript was funded by grants AEI/10.13039/501100011033, PID-2020-120412RBI100 and PDC2021-121797-I00 (F.S.-M.) from the Spanish Ministry of Economy and Competitiveness; CAM (S2017/BMD-3671-INFLAMUNE-CM) from the Comunidad de Madrid (F.S.-M.), CIBERCV (CB16/11/00272) and BIOIMID PIE13/041 from the Instituto de Salud Carlos “la Caixa” Foundation under the project code HR17-00016. The current research is supported by AECC-Coordinated Grant 2022 (PRYCO223002PEIN). The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015- 0505). IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, CEX2020-001039-S). S.G.D. is supported by a grant from the Spanish Ministry of Universities.es_ES
dc.format.number1es_ES
dc.format.volume24es_ES
dc.identifier.citationInt J Mol Sci. 2022 Dec 23;24(1):250.es_ES
dc.identifier.doi10.3390/ijms24010250es_ES
dc.identifier.e-issn1422-0067es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.identifier.pubmedID36613706es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16401
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/AEI/10.13039/501100011033es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PID-2020-120412RBI100es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PDC2021-121797-I00es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/S2017/BMD-3671-INFLAMUNE-CMes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/CB16/11/00272es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/BIOIMID PIE13/041es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/HR17-00016es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PRYCO223002PEINes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/MINECO/CEX2020-001039-Ses_ES
dc.relation.publisherversion10.3390/ijms24010250es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoriaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshMicroRNAses_ES
dc.subject.meshT-Lymphocyteses_ES
dc.subject.meshRNA Interferencees_ES
dc.subject.meshPrecision Medicinees_ES
dc.subject.meshImmunotherapyes_ES
dc.titleMicroRNAs in T Cell-Immunotherapy.es_ES
dc.typereviewes_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication

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