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Association between a Mediterranean lifestyle and growth differentiation factor 15: The seniors ENRICA-2 cohort

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dc.contributor.authorSotos-Prieto, Mercedes
dc.contributor.authorMaroto-Rodriguez, Javier
dc.contributor.authorOrtolá, Rosario
dc.contributor.authorMartinez-Gomez, David
dc.contributor.authorGarcía-Esquinas, Esther
dc.contributor.authorBuño-Soto, Antonio
dc.contributor.authorRodríguez-Artalejo, Fernando
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderPlan Nacional de I+D+i (España)es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)es_ES
dc.contributor.funderPlan Nacional de Drogas (España)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación Soria Melguizoes_ES
dc.contributor.funderAutonomous University of Madrid (España)es_ES
dc.contributor.funderComunidad de Madrid (España)es_ES
dc.date.accessioned2024-01-09T11:23:10Z
dc.date.available2024-01-09T11:23:10Z
dc.date.issued2023-02-01
dc.description.abstractBackground: Growth Differentiation Factor 15 (GDF-15) is a marker of inflammation and oxidative stress that has been associated with multiple age-related chronic diseases. Since lifestyle is key for preventing these adverse health outcomes, we examined the association between a Mediterranean lifestyle and GDF-15 serum concentrations in Spanish older adults. Methods: We used cross-sectional data from 2502 older adults participating in the Seniors ENRICA-2 cohort. Adherence to the Mediterranean lifestyle was assessed with the 27-item MEDLIFE index, divided into three blocks: 1) "Mediterranean food consumption, 2) Mediterranean dietary habits, 3) Physical activity, rest, social habits, and conviviality". Analyses of the association between the MEFLIFE index and GDF-15 concentrations were performed using multivariable linear regression models adjusting for the main potential confounders. Results: The MEDLIFE index was inversely associated with GDF-15. Compared with participants in the lowest quartile of the MEDLIFE score, GDF-15 mean percentage differences (95% CI) were -3.0% (-8.0, 2.3) for the second quartile, -8.7% (-13.0, -4.1) for the third quartile, and -10.1% (-15.0, -4.9) for the fourth quartile (p-trend<0.001). Block 3 of MEDLIFE, and particularly doing sufficient physical activity, adequate sleep duration, and participating in collective sports, was individually linked to lower concentrations of GDF-15. Results remained similar after excluding participants with cardiovascular disease, type 2 diabetes, or obesity. Conclusions: A Mediterranean lifestyle was associated with reduced levels of GDF-15, suggesting that a combination of multiple lifestyles may be an integral approach to reduce chronic inflammation and disease burden in older adults.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by the Institute of Health Carlos III; the Secretary of R+D+I; the European Regional Development Fund/European Social Fund (FIS grants 19/319, 20/00896); the National Plan on Drugs (grant 2020/17); Fundación Soria Melguizo (MITOFUN project); Ministry of Science, Innovation and Universities (RYC 2018-02069I to MSP); Universidad Autonóma de Madrid (FPI contract to JMR); FACINGLCOVID-CM project, Funding REACT EU Program (Comunidad de Madrid, European Regional Development Fund). Reagents for measuring Growth Differentiation Factor 15 have been provided by Roche Diagnostics International through a Research Agreement with the FUAM (Fundación de la Universidad Autonóma de Madrid). The funding agencies had no role in study design, data collection and analysis, interpretation of results, manuscript preparation or the decision to submit this manuscript for publication.es_ES
dc.format.page192-198es_ES
dc.format.volume195es_ES
dc.identifier.citationFree Radic Biol Med. 2023 Feb 1:195:192-198.es_ES
dc.identifier.doi10.1016/j.freeradbiomed.2022.12.090es_ES
dc.identifier.e-issn1873-4596es_ES
dc.identifier.journalFree radical biology & medicinees_ES
dc.identifier.pubmedID36584798es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16905
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/2020/17es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/RYC2018-02069Ies_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI19/319es_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI20 - Proyectos de investigacion en salud (AES 2020). Modalidad proyectos de investigación en salud. (2020)/PI20/00896es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.freeradbiomed.2022.12.090es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectBiomarkerses_ES
dc.subjectPhysical activityes_ES
dc.subjectDiet indexes_ES
dc.subjectInflammaginges_ES
dc.subject.meshGrowth Differentiation Factor 15es_ES
dc.subject.meshLife Stylees_ES
dc.subject.meshAgedes_ES
dc.subject.meshHumanses_ES
dc.subject.meshCross-Sectional Studieses_ES
dc.subject.meshInflammationes_ES
dc.subject.meshSpaines_ES
dc.titleAssociation between a Mediterranean lifestyle and growth differentiation factor 15: The seniors ENRICA-2 cohortes_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication429a9626-da12-4fcc-83f2-f24dafa525ec
relation.isAuthorOfPublicationcd6c57f6-1b5a-4269-85da-b690a939d667
relation.isAuthorOfPublication.latestForDiscovery429a9626-da12-4fcc-83f2-f24dafa525ec
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