Publication:
Capsule Enlargement in Cryptococcus neoformans Is Dependent on Mitochondrial Activity

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dc.contributor.authorTrevijano-Contador, Nuria
dc.contributor.authorRossi, Suelen Andreia
dc.contributor.authorAlves, Elisabete
dc.contributor.authorLandín-Ferreiroa, Santiago
dc.contributor.authorZaragoza, Oscar
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderCiências sem fronteiras
dc.date.accessioned2019-03-02T21:02:22Z
dc.date.available2019-03-02T21:02:22Z
dc.date.issued2017-07-31
dc.description.abstractCryptococcus neoformans is an environmental encapsulated yeast that behaves as an opportunistic pathogen in immunocompromised individuals. The capsule is the main virulence factor of this pathogen. This structure is highly dynamic, and it can change its size and structure according to the environmental conditions. During infection, C. neoformans significantly enlarges the size of the capsule by the addition of new polysaccharide. It is believed that capsule growth is an energy-cost process, but this aspect has never been addressed. In this work, we have evaluated the role of mitochondrial activity on capsule growth using specific inhibitors of the electron respiratory chain. We observed that capsule growth was impaired in the presence of inhibitors of the respiratory chain as salicylhydroxamic acid or antimycin A. Furthermore, capsule growth correlated with an increase of the mitochondrial membrane potential and higher production of reactive oxygen species. Our results confirm that capsule growth depends on mitochondrial activity, and open new insights to understand the regulation of this process.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipOZ is funded by grant SAF2014-54336-R from the SpanishMinistry for Economics and Competitivity. NT-C is supported bya FPI fellowship (reference BES-2012-051837). SR is supported bya grant from Ciências sem fronteiras (202436/2015-2). EA had agrant from Erasmus+program (Erasmus code COVILHA01).SL-F participated in this work in the frame of a Master in‘Parasitology and Microbiology: Research and Development ’from the Pharmacy and Biology Faculties from the Complutense University of Madrid.es_ES
dc.format.page1423es_ES
dc.format.volume8es_ES
dc.identifier.citationFront Microbiol. 2017;31;8:1423.es_ES
dc.identifier.doi10.3389/fmicb.2017.01423es_ES
dc.identifier.issn1664-302Xes_ES
dc.identifier.journalFrontiers in microbiologyes_ES
dc.identifier.pubmedID28824559es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7278
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-54336-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2012-051837es_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2017.01423es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCryptococcus neoformanses_ES
dc.subjectCapsule enlargementes_ES
dc.subjectMitochondriaes_ES
dc.subjectMitochondrial membrane potentiales_ES
dc.subjectReactive oxygen specieses_ES
dc.titleCapsule Enlargement in Cryptococcus neoformans Is Dependent on Mitochondrial Activityes_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationb524f086-180d-432d-a431-7a63798600f0
relation.isAuthorOfPublication46f277e7-a8a7-4920-9887-bdca9dc79ed6
relation.isAuthorOfPublication298933e5-bfff-4e88-83ec-e4d2cb6581e1
relation.isAuthorOfPublication.latestForDiscoveryb524f086-180d-432d-a431-7a63798600f0
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