Publication:
Diagnostic Mycology Laboratories Should Have a Central Role for the Management of Fungal Disease

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dc.contributor.authorMedina, Narda
dc.contributor.authorAlastruey-Izquierdo, Ana
dc.contributor.authorMercado, Danicela
dc.contributor.authorDenning, David W
dc.contributor.authorArathoon, Eduardo
dc.contributor.authorRodriguez-Tudela, Juan Luis
dc.date.accessioned2023-05-05T13:04:47Z
dc.date.available2023-05-05T13:04:47Z
dc.date.issued2022-12-08
dc.description.abstractThe absence of awareness of fungal diseases as part of the differential diagnosis in at-risk populations has severe consequences. Here, we show how the active role of laboratories can improve patients’ survival. Recently, major advances have been made in non-culture-based assays for fungal diseases, improving accuracy and turnaround time. Furthermore, with the introduction of proficiency control systems, laboratories are an easily monitored environment with good analytical accuracy. Diagnostic packages for opportunistic infections can overcome many deficiencies caused by the absence of awareness. In Guatemala, to make diagnosis accessible, we set up a diagnostic laboratory hub (DLH) providing screening for cryptococcosis, histoplasmosis and tuberculosis to a network of 13 healthcare facilities attending people living with HIV (PLWHIV). In two years, we screened 2127 newly HIV-diagnosed patients. The frequency of opportunistic infections was 21%, rising to 30.3% in patients with advanced HIV disease (<200 CD4); 8.1% of these patients had more than one infection. With the implementation of this diagnostic package, mortality decreased by 7%, a key goal of many public health interventions. Screening for serious infection in high-risk populations can partially overcome training or experiential deficiencies among clinicians for life-threatening fungal diseases.es_ES
dc.description.peerreviewedSĂ­es_ES
dc.description.sponsorshipThe program implemented in Guatemala was supported by Global Action for Fungal Infections and JYLAG, a charity foundation based in Switzerland (E.A. received this funding under the proposal: “Minimizing HIV deaths through rapid fungal diagnosis and better care in Guatemala”).es_ES
dc.format.number12es_ES
dc.format.page1285es_ES
dc.format.volume8es_ES
dc.identifier.citationJ Fungi (Basel). 2022 Dec 8;8(12):1285.es_ES
dc.identifier.doi10.3390/jof8121285es_ES
dc.identifier.e-issn2309-608Xes_ES
dc.identifier.journalJournal of fungi (Basel, Switzerland)es_ES
dc.identifier.pubmedID36547618es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16000
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jof8121285es_ES
dc.repisalud.centroISCIII::Centro Nacional de MicrobiologĂ­aes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribuciĂłn 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHIVes_ES
dc.subjectLatin Americaes_ES
dc.subjectCryptococcosises_ES
dc.subjectHistoplasmosises_ES
dc.subjectOpportunistic infectionses_ES
dc.subjectPublic healthes_ES
dc.subjectTuberculosises_ES
dc.titleDiagnostic Mycology Laboratories Should Have a Central Role for the Management of Fungal Diseasees_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication54ebd325-2b8b-440e-a985-15c295f25b8d
relation.isAuthorOfPublication0f6c083c-c0af-4b54-b7ca-ae867ce908b3
relation.isAuthorOfPublication.latestForDiscovery54ebd325-2b8b-440e-a985-15c295f25b8d
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