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Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

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dc.contributor.authorCárdenas, Casimiro
dc.contributor.authorTorres-Vargas, José Antonio
dc.contributor.authorCárdenas-Valdivia, Abel
dc.contributor.authorJurado, Nuria
dc.contributor.authorQuesada, Ana R.
dc.contributor.authorGarcía-Caballero, Melissa
dc.contributor.authorMartínez-Poveda, Beatriz
dc.contributor.authorMedina, Miguel Ángel
dc.contributor.authoraffiliation[Cárdenas,C; Torres-Vargas,JA; Jurado,N; Quesada,AR; García-Caballero,M; Martínez-Poveda,B; Medina,MÁ] Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Málaga, Spain. [Cárdenas,C] Research Support Central Services (SCAI) of the University of Málaga, Spain. [Torres-Vargas,JA; Quesada,AR; García-Caballero,M; Martínez-Poveda,B; Medina,MÁ] IBIMA (Biomedical Research Institute of Málaga), Málaga, Spain. [Cárdenas-Valdivia,A] Department of Physical Chemistry, Faculty of Sciences, University of Malaga, Malaga, Spain. [Quesada,AR; Medina,MÁ] CIBER de Enfermedades Raras (CIBERER), Málaga, Spain. [Martínez-Poveda,B] CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
dc.date.accessioned2024-02-19T15:31:40Z
dc.date.available2024-02-19T15:31:40Z
dc.date.issued2021-10-06
dc.description.abstractThe tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
dc.description.sponsorshipThis work was supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA 220, UMA18-FEDERJA-267 and PY20_00257 (Andalusian Government and FEDER) and funds from group BIO 267 (Andalusian Government). The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Vasculares” are initiatives from the ISCIII (Spain).
dc.identifier.doi10.1016/j.biopha.2021.112263
dc.identifier.e-issn1950-6007es_ES
dc.identifier.issn0753-3322
dc.identifier.journalBiomedicine & Pharmacotherapyes_ES
dc.identifier.otherhttp://hdl.handle.net/10668/4594
dc.identifier.pubmedID34626933es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18479
dc.language.isoeng
dc.publisherElsevier
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0753332221010477?via%3Dihubes
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectUltra-high-performance liquid
dc.subjectChromatography-high-resolution mass spectrometry (UHPLC–HRMS)
dc.subjectAnnona muricata
dc.subjectGraviola
dc.subjectSoursop
dc.subjectAngiogenesis
dc.subjectCromatografía líquida de alta presión
dc.subjectEspectrometría de masas
dc.subjectAnnonaceae
dc.subjectAnnona
dc.subjectNeovascularización fisiológica
dc.subject.meshAngiogenesis Inhibitors
dc.subject.meshAnimals
dc.subject.meshCattle
dc.subject.meshCell Differentiation
dc.subject.meshCell Movement
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshEndothelial Cells
dc.subject.meshMetabolome
dc.subject.meshNeovascularization, Physiologic
dc.subject.meshPhytochemicals
dc.subject.meshPlant Extracts
dc.subject.meshSpectrometry, Mass, Electrospray Ionization
dc.subject.meshAnnona
dc.titleNon-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isPublisherOfPublication7d471502-7bd5-4f7a-90a4-8274382509ef
relation.isPublisherOfPublication.latestForDiscovery7d471502-7bd5-4f7a-90a4-8274382509ef

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