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Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria

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dc.contributor.authorGomez-Florit, Manuel
dc.contributor.authorPacha-Olivenza, Miguel A
dc.contributor.authorFernandez-Calderon, Maria C
dc.contributor.authorCordoba, Alba
dc.contributor.authorGonzalez-Martin, Maria L
dc.contributor.authorMonjo, Marta
dc.contributor.authorRamis, Joana Maria
dc.date.accessioned2024-07-09T09:13:11Z
dc.date.available2024-07-09T09:13:11Z
dc.date.issued2016-03-01
dc.description.abstractMany dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success.en
dc.description.sponsorshipThis work was supported by the Conselleria d'Educacio, Cultura i Universitats of the Balearic Islands Government and the European Social Fund (contract to JMR - PD/018/2014), by the Osteology Foundation (Grant Number: 13-069) and by the Instituto de Salud Carlos III (CIBER-BBN Mobility grant to MGF). The authors thank Dr. Ferran Hierro (University of the Balearic Islands) for his technical contribution with SEM.es_ES
dc.format.page22444es_ES
dc.format.volume6es_ES
dc.identifier.citationGomez-Florit M, Pacha-Olivenza MA, Fernandez-Calderon MC, Cordoba A, Gonzalez-Martin ML, Monjo M, et al. Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Sci Rep. 2016 Mar 01;6:22444.en
dc.identifier.doi10.1038/srep22444
dc.identifier.issn2045-2322
dc.identifier.journalScientific Reportses_ES
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/10447
dc.identifier.pubmedID26925553es_ES
dc.identifier.puiL616507039
dc.identifier.scopus2-s2.0-84959567765
dc.identifier.urihttp://hdl.handle.net/20.500.12105/20254
dc.identifier.wos371037000003
dc.language.isoengen
dc.publisherNature Publishing Group
dc.relation.publisherversionhttps://dx.doi.org/10.1038/srep22444en
dc.rights.accessRightsopen accessen
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.decsDinoprostona*
dc.subject.decsTitanio*
dc.subject.decsInhibidor Tisular de Metaloproteinasa-1*
dc.subject.decsImplantes Dentales*
dc.subject.decsMetaloproteinasa 1 de la Matriz*
dc.subject.decsFemenino*
dc.subject.decsEncía*
dc.subject.decsMasculino*
dc.subject.decsAntiinflamatorios*
dc.subject.decsHumanos*
dc.subject.decsPersona de Mediana Edad*
dc.subject.decsAdulto Joven*
dc.subject.decsAdhesión Bacteriana*
dc.subject.decsCélulas Cultivadas*
dc.subject.decsInflamación*
dc.subject.decsAdhesión Celular*
dc.subject.decsQuercetina*
dc.subject.decsAdulto*
dc.subject.decsAntibacterianos*
dc.subject.decsBiopelículas*
dc.subject.decsStreptococcus mutans*
dc.subject.meshMatrix Metalloproteinase 1*
dc.subject.meshBiofilms*
dc.subject.meshYoung Adult*
dc.subject.meshAdult*
dc.subject.meshAnti-Bacterial Agents*
dc.subject.meshCell Adhesion*
dc.subject.meshHumans*
dc.subject.meshInflammation*
dc.subject.meshCells, Cultured*
dc.subject.meshBacterial Adhesion*
dc.subject.meshAnti-Inflammatory Agents*
dc.subject.meshGingiva*
dc.subject.meshMiddle Aged*
dc.subject.meshMale*
dc.subject.meshDental Implants*
dc.subject.meshFemale*
dc.subject.meshDinoprostone*
dc.subject.meshStreptococcus mutans*
dc.subject.meshTissue Inhibitor of Metalloproteinase-1*
dc.subject.meshQuercetin*
dc.subject.meshTitanium*
dc.titleQuercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteriaen
dc.typeresearch articleen
dspace.entity.typePublication
relation.isPublisherOfPublication301fb00e-338e-4f8c-beaa-f9d8f4fefcc0
relation.isPublisherOfPublication.latestForDiscovery301fb00e-338e-4f8c-beaa-f9d8f4fefcc0

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