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Survey of Crimean-Congo Hemorrhagic Fever Enzootic Focus, Spain, 2011-2015

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dc.contributor.authorNegredo, Anabel
dc.contributor.authorHabela, Miguel Ángel
dc.contributor.authorRamirez de Arellano, Eva
dc.contributor.authorDíez-Fuertes, Francisco
dc.contributor.authorLasala, Fátima
dc.contributor.authorLópez, Pablo
dc.contributor.authorLasala, Fátima
dc.contributor.authorSarriá, Ana
dc.contributor.authorLabiod, Nuria
dc.contributor.authorCalero-Bernal, Rafael
dc.contributor.authorArenas, Miguel
dc.contributor.authorTenorio, Antonio
dc.contributor.authorEstrada-Peña, Agustín
dc.contributor.authorSánchez-Seco, María Paz
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderPlan Nacional de I+D+i (España)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderFederación Española de Enfermedades Raras
dc.date.accessioned2025-01-10T12:34:59Z
dc.date.available2025-01-10T12:34:59Z
dc.date.issued2019-06
dc.description.abstractDuring 2011-2015, we conducted a Crimean-Congo hemorrhagic fever virus (CCHFV) survey in captured ticks that were feeding mainly on wild and domestic ungulates in Spain, where presence of this virus had been reported previously. We detected CCHFV RNA in Hyalomma lusitanicum and H. marginatum ticks for 3 of the 5 years. The rate of infected ticks was 2.78% (44/1,579), which was similar to those for other countries in Europe with endemic foci for CCHFV (Kosovo, Bulgaria, and Albania). These data confirm the established spread of CCHFV into western Europe. Phylogenetic study of the small RNA segment showed Africa-3 clade as the only genotype identified, although we observed cocirculation of genetic variants during 2011 and 2015. We could not rule out genetic reassortments because of lack of sequence data for the medium and large RNA segments of the virus genome.
dc.description.peerreviewedSí
dc.description.sponsorshipThis study was supported by Instituto de Salud Carlos III (Projects RD12/0018/0006 and RD16CIII/0003/0003), Red de Enfermedades Tropicales Subprogram Redes Temáticas de Investigación Cooperativa en Salud Plan Estatal de I+D+I 2013–2016, Federación Española de Enfermedades Rares (Una Manera de Hacer Europa), and European Project EMERGE.
dc.format.number6
dc.format.page1177-1184
dc.format.volume25
dc.identifier.citationNegredo A, Habela MÁ, Ramírez de Arellano E, Diez F, Lasala F, López P, Sarriá A, Labiod N, Calero-Bernal R, Arenas M, Tenorio A, Estrada-Peña A, Sánchez-Seco MP. Survey of Crimean-Congo Hemorrhagic Fever Enzootic Focus, Spain, 2011-2015. Emerg Infect Dis. 2019 Jun;25(6):1177-1184.
dc.identifier.doi10.3201/eid2506.180877
dc.identifier.e-issn1080-6059
dc.identifier.issn1080-6040
dc.identifier.journalEmerging infectious diseases
dc.identifier.pubmedID31107219
dc.identifier.urihttps://hdl.handle.net/20.500.12105/25992
dc.language.isoeng
dc.publisherCenters for Disease Control and Prevention (CDC)
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RD12%2F0018%2F0006/ES/Enfermedades tropicales/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16CIII/0003/0003
dc.relation.publisherversionhttps://doi.org/10.3201/eid2506.180877
dc.repisalud.centroISCIII::Centro Nacional de Microbiología (CNM)
dc.repisalud.institucionISCIII
dc.rights.accessRightsopen access
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCCHFV
dc.subjectCrimean Congo hemorrhagic fever virus
dc.subjectCrimean-Congo hemorrhagic fever
dc.subjectHyalomma spp. ticks
dc.subjectSpain
dc.subjectEndemic circulation
dc.subjectEnzootic focus
dc.subjectMolecular epidemiology survey
dc.subjectPhylogenetic analysis
dc.subjectReverse transcription PCR
dc.subjectTick-borne infections
dc.subjectVector-borne infections
dc.subjectViruses
dc.subjectZoonoses
dc.subject.meshAnimals
dc.subject.meshArthropod Vectors
dc.subject.meshGenome, Viral
dc.subject.meshGeography
dc.subject.meshHemorrhagic Fever Virus, Crimean-Congo
dc.subject.meshHemorrhagic Fever, Crimean
dc.subject.meshHumans
dc.subject.meshPhylogeny
dc.subject.meshPublic Health Surveillance
dc.subject.meshSpain
dc.subject.meshTicks
dc.subject.meshZoonoses
dc.titleSurvey of Crimean-Congo Hemorrhagic Fever Enzootic Focus, Spain, 2011-2015
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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