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Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.

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dc.contributor.authorBraza, Mounia S
dc.contributor.authorGarcia, Mercedes
dc.contributor.authorBrahmachary, Manisha
dc.contributor.authorPothula, Venu
dc.contributor.authorFay, Francois
dc.contributor.authorBoros, Peter
dc.contributor.authorWerner, Sherry A
dc.contributor.authorGinhoux, Florent
dc.contributor.authorMulder, Willem J M
dc.contributor.authorOchando, Jordi
dc.contributor.authorConde-San Román, Patricia
dc.contributor.authorCortegano, Isabel
dc.contributor.funderNational Institutes of Health (Estados Unidos)
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.date.accessioned2020-06-15T06:22:07Z
dc.date.available2020-06-15T06:22:07Z
dc.date.issued2018
dc.description.abstractThe colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipCancer Center. Grant Number: P30 CA196521 National Institute of Health. Grant Numbers: R01 HL118440, R01 HL125703, R01 CA155432 Ministerio de Economia y Competitividad. Grant Number: SAF2016‐80031‐R COSTes_ES
dc.format.number5es_ES
dc.format.page1247-1255es_ES
dc.format.volume18es_ES
dc.identifier.citationAm J Transplant . 2018 May;18(5):1247-1255.es_ES
dc.identifier.doi10.1111/ajt.14645es_ES
dc.identifier.e-issn1600-6143es_ES
dc.identifier.journalAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeonses_ES
dc.identifier.pubmedID29314558es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10395
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/P30CA196521es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/R01HL118440es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/R01HL125703es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/R01CA155432es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/SAF2016‐80031‐Res_ES
dc.relation.publisherversionhttps://doi.org/10.1111/ajt.14645es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshHeart Transplantationes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCell Differentiationes_ES
dc.subject.meshCell Proliferationes_ES
dc.subject.meshFemalees_ES
dc.subject.meshHumanses_ES
dc.subject.meshImmune Tolerancees_ES
dc.subject.meshMacrophage Colony-Stimulating Factores_ES
dc.subject.meshMacrophageses_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshMice, Inbred BALB Ces_ES
dc.subject.meshMice, Inbred C57BLes_ES
dc.subject.meshNeutrophilses_ES
dc.subject.meshSignal Transductiones_ES
dc.subject.meshTransplantation Tolerancees_ES
dc.titleNeutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationf4411902-c52c-4e77-afff-0f9d9e8d9e9f
relation.isAuthorOfPublication17bca9fc-64b5-4c8d-970b-648afc36cf55
relation.isAuthorOfPublication9c88d399-c1a6-4752-a513-f36ea53e647e
relation.isAuthorOfPublication.latestForDiscoveryf4411902-c52c-4e77-afff-0f9d9e8d9e9f

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